Beneficial effects of Omega-3 polyunsaturated fatty acids in treatment of non-alcoholic fatty liver disease in rats. | ||
| Benha Veterinary Medical Journal | ||
| Article 18, Volume 40, Issue 2, July 2021, Pages 86-90 PDF (447.85 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bvmj.2021.65003.1351 | ||
| Authors | ||
| Samy Hussein1; Yakout Elsenosi2; Mohamed Khalid3; Marwa Mahmoud Fawzy Atta* 4 | ||
| 1Department of Biochemistry, Faculty of Veterinary Medicine, Benha University, Egypt. | ||
| 2Department of Biochemistry , faculty of Veterinary medicine, Benha University,Egypt. | ||
| 3Department of Biochemistry, Faculty of Veterinary. Medicine., Benha University, Egypt. | ||
| 4Faculty of Vetrinary medicine ,Benha University | ||
| Abstract | ||
| Nonalcoholic fatty liver disease (NAFLD) is sickness with different causes and it is the most hepatic illness. The objective of this work is to investigate the bimolecular changes in a model of high fat diet induced- NAFLD in rats. Also, the hypolipidemic, antioxidant and anti-inflammatory effects of omega-3 were clarify via evaluation of some biochemical and molecular parameters in the liver tissue of rats.Twenty one adult white albino rats were divided into three groups. Group I (Normal control): received no drugs and fed balanced diet, Group II (NAFLD- induced group): rats fed high fat diet for 8 weeks followed by normal basal ration for additional 8 weeks. Group III (NAFLD + omega-3): rats administrated omega-3 (300 mg/kg b.wt/day), orally for 8 weeks post-induction of NAFLD. The obtained results showed a significant increase in serum Total cholesterol and Triacylglycerols (TAG) concentrations, L-MDA and TAC in liver tissuewith significant up-regulation in CPT-1α, FAS, SREBP-1c, PPAR-α, Nrf2 and TAK1gene expression in NAFLD-induced rats. Treatment with Omega-3 to NAFLD induced rats potentially improved molecular hepatic cell function and oxidative alterations related to NAFLD near its normal ranges. Meanwhile, histo-pathological findings supported that Omeg-3 markedly attenuates harmful effects of NAFLD and protected liver cell. On conclusion, Omega-3 plays an important role as potent anti-oxidant, anti-obesity, anti-inflammatory via inhibition of hepatic steatosis and oxidative stress singling. | ||
| Keywords | ||
| NAFLD; Omega-3; oxidative stress; inflammatory biomarkers; Histopathology | ||
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