THE EFFECTS OF TWO ANTIPSYCHOTIC DRUGS AND PROLACTIN ON TOXOPLASMA GONDII TACHYZOITES IN VIVO | ||
| Journal of the Egyptian Society of Parasitology | ||
| Article 14, Volume 51, Issue 2, August 2021, Pages 355-364 PDF (1.09 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jesp.2021.193315 | ||
| Authors | ||
| Asmaa Hosney Deeb1; ABD-ALLAH ABD-ELSAMEE HASSAN2; MOHAMED E. M. TOLBA2; ENAS A. HUSEEIN2 | ||
| 1parasitology department, faculty of medicine, Assiut university | ||
| 2Department of Medical Parasitology, Faculty of Medicine, Assiut University, Egypt | ||
| Abstract | ||
| Chronic toxoplasmosis is associated with psychotic disorders. Multiple in vitro studies showed that many antipsychotic medications have anti-Toxoplasma activity. Meanwhile, there is very limited data regarding the inhibitory effect of them on Toxoplasma in vivo. This study evaluated the activity of Chlorpromazine®, Clozapine®, and prolactin (a pituitary gland hormone) on toxoplasmosis infected rats. Clean laboratory breed rats were chronically infected with non-virulent T. gondii strain and classified into 8 groups: negative, positive control groups, chlorpromazine, clozapine, and metoclopramide drug control groups, and 3 infected treated groups. Rats’ sera were screened with ELISA test to evaluate level of dopamine, interferon gamma, and prolactin. All drugs were effective against T. gondii in infected rats. Dopamine level and INF-γ level were significantly decreased in chlorpromazine infected treated rats. There was significant decrease of dopamine level and increase of prolactin level in clozapine infected treated rats. In metoclopramide infected treated rats prolactin level significantly increased, but INF-γ level significantly decreased. | ||
| Keywords | ||
| Rats; Toxoplasma gondii; Antipsychotic drugs; ELISA | ||
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