TALKAHN, M., MAGED, K., EL KILANY, H., MOHAMED, E., MOHAMED, H., DAWOD, A. (2021). ASSESSMENT OF CARDIAC FUNCTIONS IN EGYPTIAN CHRONIC HEPATITIS C PATIENTS BEFORE AND AFTER TREATMENT WITH DIRECTLY ACTING ANTIVIRALS. test, 51(2), 405-410. doi: 10.21608/jesp.2021.193327
MOHAMED G. TALKAHN; KHALED H. ABDEL MAGED; HESHAM H. R. EL KILANY; ESLAM S. MOHAMED; HAITHAM G. MOHAMED; AYMAN G. A. DAWOD. "ASSESSMENT OF CARDIAC FUNCTIONS IN EGYPTIAN CHRONIC HEPATITIS C PATIENTS BEFORE AND AFTER TREATMENT WITH DIRECTLY ACTING ANTIVIRALS". test, 51, 2, 2021, 405-410. doi: 10.21608/jesp.2021.193327
TALKAHN, M., MAGED, K., EL KILANY, H., MOHAMED, E., MOHAMED, H., DAWOD, A. (2021). 'ASSESSMENT OF CARDIAC FUNCTIONS IN EGYPTIAN CHRONIC HEPATITIS C PATIENTS BEFORE AND AFTER TREATMENT WITH DIRECTLY ACTING ANTIVIRALS', test, 51(2), pp. 405-410. doi: 10.21608/jesp.2021.193327
TALKAHN, M., MAGED, K., EL KILANY, H., MOHAMED, E., MOHAMED, H., DAWOD, A. ASSESSMENT OF CARDIAC FUNCTIONS IN EGYPTIAN CHRONIC HEPATITIS C PATIENTS BEFORE AND AFTER TREATMENT WITH DIRECTLY ACTING ANTIVIRALS. test, 2021; 51(2): 405-410. doi: 10.21608/jesp.2021.193327

ASSESSMENT OF CARDIAC FUNCTIONS IN EGYPTIAN CHRONIC HEPATITIS C PATIENTS BEFORE AND AFTER TREATMENT WITH DIRECTLY ACTING ANTIVIRALS

Journal of the Egyptian Society of Parasitology
Article 20, Volume 51, Issue 2, August 2021, Pages 405-410    PDF (680.33 K)
Document Type: Original Article
DOI: 10.21608/jesp.2021.193327
Authors
MOHAMED G. TALKAHN1; KHALED H. ABDEL MAGED1; HESHAM H. R. EL KILANY1; ESLAM S. MOHAMED1; HAITHAM G. MOHAMED2; AYMAN G. A. DAWOD1
1Department of Internal Medicine, Hepatogastroenterology and Endoscopy
2Department of Cardiology
Abstract
Hepatitis C virus (HCV) is one of the leading causes of chronic liver disease worldwide. It
poses a serious health risk. Liver cirrhosis of is also linked to a variety of cardiovascular abnormalities.
Nowadays, direct-acting antivirals (DAAs) for hepatitis C have the potential to reduce
this disease burden, but their potential long-term cardiac effects are unknown. The aim of this
work was to see how direct-acting antivirals affect the cardiac functions of naive Egyptians
with chronic hepatitis C.
The 90 treatment-naive adult patients with chronic hepatitis C were divided into two groups
(cirrhotic and non-cirrhotic). Only two patients within the non-cirrhotic group and a patient
among cirrhotic patients showed nonspecific ST segment changes which remained unchanged
after treatments. Two non-cirrhotic patients and four cirrhotic patients showed T wave inversion,
which remained static post treatment, but without significant difference in corrected QT
interval before & after treatment between groups.
Keywords
Egypt; Patients; HCV; Liver cirrhosis; cardiac functions; Direct-acting antivirals (DAAs)
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