Saad-eldin, R., Fathy, N., El-Nashar, A., Abo Al-Fadl, E. (2021). The relation of systemic lupus erythematosus activity and histopathology of renal biopsy. test, 25(2), 100-105. doi: 10.21608/smj.2021.74553.1248
Rana Saad-eldin; Nehal Fathy; Afaf Taha El-Nashar; Esam Mohammed Abo Al-Fadl. "The relation of systemic lupus erythematosus activity and histopathology of renal biopsy". test, 25, 2, 2021, 100-105. doi: 10.21608/smj.2021.74553.1248
Saad-eldin, R., Fathy, N., El-Nashar, A., Abo Al-Fadl, E. (2021). 'The relation of systemic lupus erythematosus activity and histopathology of renal biopsy', test, 25(2), pp. 100-105. doi: 10.21608/smj.2021.74553.1248
Saad-eldin, R., Fathy, N., El-Nashar, A., Abo Al-Fadl, E. The relation of systemic lupus erythematosus activity and histopathology of renal biopsy. test, 2021; 25(2): 100-105. doi: 10.21608/smj.2021.74553.1248

The relation of systemic lupus erythematosus activity and histopathology of renal biopsy

Sohag Medical Journal
Article 13, Volume 25, Issue 2, April 2021, Pages 100-105    PDF (761.26 K)
Document Type: Original Article
DOI: 10.21608/smj.2021.74553.1248
Authors
Rana Saad-eldin* 1; Nehal Fathy2; Afaf Taha El-Nashar3; Esam Mohammed Abo Al-Fadl4
1Department of rheumatology and rehabilitation, Sohag faculty of medicine, Sohag university
2Rheumatology & rehabilitation department , assiut faculty of medicine , assiut university
3Department of Pathology, Faculty of Medicine, Sohag
4Department of Internal Medicine and Department of Rheumatology, Rehabilitation and Physical medicine,Faculty of Medicine- Sohag University.
Abstract
Background: About 50% of patients with systemic lupus erythematosus (SLE) develop lupus nephritis during the course of their disease. Up to 10% of these patients reach the end-stage renal disease.
Purpose: Detection of the relationship between the activity of systemic lupus erythematosus (SLE) and histopathology of renal biopsy.
Patients and methods: This study is cross- sectional and observational. It included one hundred Egyptian patients with SLE according to the 2015 ACR/SLICC Revised criteria. SLE Disease Activity Index (SLEDAI) and renal biopsy were done to all patients in addition to the routine investigations.
Results: Of the one hundred patients; 9 were males and 91 were females with a mean age ± standard deviation of 32.28 ± 9.59 years and a median of 31.5 years. The mean value SLEDAI was 11.92 ± 3.92. Lupus nephritis (LN) was found in 85 patients (85%) with 5 patients (5%) having class 1, 73 patients (73%) having class 2 and 7 patients (7%) having class3 LN.
Conclusion: Ther relationship between the SLEDAI score and the histopathological study of renal biopsy in patients with SLE is strong and significant with a mean value of SLEDAI directly proportional to the class of LN.
Keywords
lupus nephritis; renal biopsy; SLEDAI score
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