mohamed, M., aly, M., Hamed, S., Gawish, F., zaghla, H., khaled, M., ibrahim, S., ELSAWY, A. (2021). HPLC DETECTION OF SERUM AND URINARY PARAPHENYLENE DIAMINE (PPD) LEVEL AND ITS METABOLITES IN RELATION TO CARDIAC TOXICITY. test, 21(3), 31-42. doi: 10.21608/ejfsat.2020.32659.1153
marwa issak mohamed; mona mohamed aly; Sara Hamed; fatma Gawish; hanan elsayed zaghla; mahmoud khaled; Samah fathy ibrahim; AHMED SAMIR ELSAWY. "HPLC DETECTION OF SERUM AND URINARY PARAPHENYLENE DIAMINE (PPD) LEVEL AND ITS METABOLITES IN RELATION TO CARDIAC TOXICITY". test, 21, 3, 2021, 31-42. doi: 10.21608/ejfsat.2020.32659.1153
mohamed, M., aly, M., Hamed, S., Gawish, F., zaghla, H., khaled, M., ibrahim, S., ELSAWY, A. (2021). 'HPLC DETECTION OF SERUM AND URINARY PARAPHENYLENE DIAMINE (PPD) LEVEL AND ITS METABOLITES IN RELATION TO CARDIAC TOXICITY', test, 21(3), pp. 31-42. doi: 10.21608/ejfsat.2020.32659.1153
mohamed, M., aly, M., Hamed, S., Gawish, F., zaghla, H., khaled, M., ibrahim, S., ELSAWY, A. HPLC DETECTION OF SERUM AND URINARY PARAPHENYLENE DIAMINE (PPD) LEVEL AND ITS METABOLITES IN RELATION TO CARDIAC TOXICITY. test, 2021; 21(3): 31-42. doi: 10.21608/ejfsat.2020.32659.1153

HPLC DETECTION OF SERUM AND URINARY PARAPHENYLENE DIAMINE (PPD) LEVEL AND ITS METABOLITES IN RELATION TO CARDIAC TOXICITY

The Egyptian Journal of Forensic Sciences and Applied Toxicology
Article 4, Volume 21, Issue 3, September 2021, Pages 31-42    PDF (462.4 K)
Document Type: Original Article
DOI: 10.21608/ejfsat.2020.32659.1153
Authors
marwa issak mohamed* 1; mona mohamed aly2; Sara Hamed3; fatma Gawish4; hanan elsayed zaghla5; mahmoud khaled6; Samah fathy ibrahim7; AHMED SAMIR ELSAWY6
1department of forensic and clinical toxicology cairo university
2department of forensic medicine and clinical toxicology cairo university
3Forensic & Clinical Toxicology Department, Faculty of medicine, Cairo University
4Luxor international hospital
5department of critical medicine cairo university
6department of critical care cairo university
7department of forensic medicine and toxicology princess Noura University Saudi Arabia
Abstract
Hair dye poisoning is an emerging big problem in Upper Egypt. The main component of hair dye causing toxicity is para-phenylenediamine (PPD). Ingestion of PPD could be accidental or suicidal. After oral intake it is metabolized in the liver into N-mono- (MAPPD) and N,N′- diacetylated (DAPPD) metabolites. Tissue damage after PPD ingestions occurs due to increased levels of free radical and oxidative stress that deplete tissue glutathione. Cardiac toxicity is a complication of PPD poisoning. It could be manifested by hypotension, different patterns of arrhythmia; in addition, myocarditis and elevated cardiac biomarkers were also found. Serum and urinary levels of PPD, N-acetyl-p-phenylenediamine (MAPPD) and N--diacetyl-p-phenylenediamine (DAPPD) were measured by HPLC. A prospective cohort study was planned to determine relation between the serum and urinary PPD, N-acetyl-p-phenylenediamine (MAPPD) and N,on -diacetyl-p-phenylenediamine (DAPPD) levels with cardiac manifestations of poisoned patient. Forty patients completed the diagnosis to have acute poisoning following hair dye ingestion. PPD and its metabolite concentrations did not show any significant correlation with the prevalence of cardiac toxicity and could not predict its occurrence among studied patient (p-value< .05)
Keywords
Key words: Hair dye; ppd; cardiac
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