Anwer, H., Hani, B., El-Shaer, N., Allam, M. (2021). Irisin contributes to the hepatoprotective effect of vitamin D in a choline deficient diet induced nonalcoholic fatty liver disease rat model.. test, 41(4), 509-524. doi: 10.21608/besps.2021.61041.1093
Hala Magdy Anwer; Basma Mohamed Hani; Noha Osama El-Shaer; Mona Maher Allam. "Irisin contributes to the hepatoprotective effect of vitamin D in a choline deficient diet induced nonalcoholic fatty liver disease rat model.". test, 41, 4, 2021, 509-524. doi: 10.21608/besps.2021.61041.1093
Anwer, H., Hani, B., El-Shaer, N., Allam, M. (2021). 'Irisin contributes to the hepatoprotective effect of vitamin D in a choline deficient diet induced nonalcoholic fatty liver disease rat model.', test, 41(4), pp. 509-524. doi: 10.21608/besps.2021.61041.1093
Anwer, H., Hani, B., El-Shaer, N., Allam, M. Irisin contributes to the hepatoprotective effect of vitamin D in a choline deficient diet induced nonalcoholic fatty liver disease rat model.. test, 2021; 41(4): 509-524. doi: 10.21608/besps.2021.61041.1093

Irisin contributes to the hepatoprotective effect of vitamin D in a choline deficient diet induced nonalcoholic fatty liver disease rat model.

Bulletin of Egyptian Society for Physiological Sciences
Article 6, Volume 41, Issue 4, October 2021, Pages 509-524    PDF (558.44 K)
Document Type: Original Article
DOI: 10.21608/besps.2021.61041.1093
Authors
Hala Magdy Anwer* 1; Basma Mohamed Hani2; Noha Osama El-Shaer1; Mona Maher Allam1
1Physiology Department, Faculty of Medicine, Benha University, Benha, Egypt
2Community Medicine Department, Faculty of Medicine, Benha University, Benha Egypt
Abstract
Non-alcoholic fatty liver disease (NAFLD) represents a growing cause of liver morbidity and mortality globally with no proven effective therapy yet. The aim of this research is to investigate the effect of vitamin D treatment on choline deficient (CD) diet-induced nonalcoholic fatty liver disease (NAFLD) like lesions in rats, with the possible involvement of irisin in this effect.
Thirty-two rats were divided into 4 equal groups; control group, vitamin D group, CD diet group, CD diet+ vitamin D group. It was found that CD diet led to significant elevations in liver weight and index, serum liver enzymes, hepatic triglycerides (TG), malondialdehyde (MDA), inflammatory markers with significant decreases in serum 25-(OH) D3, irisin, hepatic antioxidants and peroxisome proliferator–activated receptor alpha (PPAR–α). Administration of vitamin D caused a significant improvement in all previous parameters, these results were supported by histopathological examination.
It seems that vitamin D supplementation significantly reduced NAFLD induced by CD diet even in part due to irisin.
Keywords
vitamin D; choline-deficient diet; nonalcoholic fatty liver disease (NAFLD); irisin; peroxisome proliferator activated receptor–α (PPAR- α)
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