Impact of electronic cigarette vaping on the cytoarchitecture of the tongue in the adult male albino rat | ||
| Zagazig University Medical Journal | ||
| Article 21, Volume 28, Issue 6, November 2022, Pages 1346-1354 PDF (570.98 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/zumj.2021.88065.2301 | ||
| Authors | ||
| Dalia A. mandour1; Sara Mohamed Saber* 2; Rania Hassan Mohamed Soliman2; Marwa Tharwat Abdelfattah3 | ||
| 1Department of Human Anatomy and Embryology, Faculty of Medicine, Zagazig University, Egypt | ||
| 2Department of Human Anatomy and Embryology, Faculty of Medicine, Zagazig University, Egypt | ||
| 3Department of Human Anatomy and Embryology, Faculty of Medicine, Zagazig university, Egypt | ||
| Abstract | ||
| Background: Electronic cigarettes (E-cigs) are marketed as an alternative and replacement domain to the traditional cigarette smoking in many societies for the rescue of smoking cessation. Nevertheless, the vape of E-cigs produce different harmful chemical compounds and carcinogens. Aim: To clarify the histopathological changes that may take place in rat’s tongue after exposure to E-cigs and to assess the possible amelioration of such changes after giving up vaping. Methods: Thirty adult male albino rats were divided into three equal groups. Control group: exposed to fresh air for 4weeks. Exposed group: exposed to smoke vapor of 1ml burnt E-liquid for 1 hour, 5 consecutive days/ week for 4 weeks. Withdrawal group: exposed to the same dose and duration of smoke vapor like group 2 then left without exposure for another 4 weeks. By the end of the experiment, animals were weighted and the tongue was excised and processed for hematoxylin& eosin and Alcian blue/periodic acid Schiff’s staining and for proliferating cell nuclear antigen (PCNA) immunohistochemical study. Also, serum malondialdehyde and superoxide dismutase activity were determined. Results: E-cigs exposure hampered the cytoarchitecture of the tongue with loss of some papillae and hyperkeratosis of the others along with increased PCNA immunoreactivity and its area percentage. Also, E-cigs exposure led to redox imbalance. Obviously, stoppage of E-cigs exposure resulted in partial amelioration of histological and biochemical changes. Conclusion: E-cigs vaping produced proliferative changes that impose a metaplasia in the tongue and their withdrawal revealed some degree of improvement. | ||
| Keywords | ||
| Keywords: Electronic cigarettes; Vaping; Rat's Tongue; Withdrawal; Electronic cigarettes liquid | ||
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