khedr, M., El Desouky, M., Shafei, A., Mostafa, R., Hasanin, A., Habib, E., Abdelhakim, H., Matboly, M. (2022). Cardioprotective Effect Of Cyanidin-3-O-Glucosidein Ischemic Heart Is Mediated Via Inhibition Of Autophagy. test, 65(5), 179-186. doi: 10.21608/ejchem.2021.95695.4494
Mohammad khedr; Mohamed Ali El Desouky; Ayman Shafei; Randa Mostafa; Amany Hasanin; Eman Habib; Heba Abdelhakim; Marwa Matboly. "Cardioprotective Effect Of Cyanidin-3-O-Glucosidein Ischemic Heart Is Mediated Via Inhibition Of Autophagy". test, 65, 5, 2022, 179-186. doi: 10.21608/ejchem.2021.95695.4494
khedr, M., El Desouky, M., Shafei, A., Mostafa, R., Hasanin, A., Habib, E., Abdelhakim, H., Matboly, M. (2022). 'Cardioprotective Effect Of Cyanidin-3-O-Glucosidein Ischemic Heart Is Mediated Via Inhibition Of Autophagy', test, 65(5), pp. 179-186. doi: 10.21608/ejchem.2021.95695.4494
khedr, M., El Desouky, M., Shafei, A., Mostafa, R., Hasanin, A., Habib, E., Abdelhakim, H., Matboly, M. Cardioprotective Effect Of Cyanidin-3-O-Glucosidein Ischemic Heart Is Mediated Via Inhibition Of Autophagy. test, 2022; 65(5): 179-186. doi: 10.21608/ejchem.2021.95695.4494

Cardioprotective Effect Of Cyanidin-3-O-Glucosidein Ischemic Heart Is Mediated Via Inhibition Of Autophagy

Egyptian Journal of Chemistry
Article 17, Volume 65, Issue 5, May 2022, Pages 179-186    PDF (1.02 M)
Document Type: Original Article
DOI: 10.21608/ejchem.2021.95695.4494
Authors
Mohammad khedr1; Mohamed Ali El Desouky* 2; Ayman Shafei3; Randa Mostafa4; Amany Hasanin5; Eman Habib6; Heba Abdelhakim7; Marwa Matboly8
1Biochemistry, Faculty of Science, Cairo Univ
2Professor of Biochemistry department. Faculty of Science Cairo Univ.
3Dean of faculty of medicine MTI University.
4Prof of clinical physiology Benha college of medicine Randa.mostafa@fmed.bu. Edu. Eg
5Professor of Clinical pharmacology department. Ain shams University faculty of medicine.
6Professor of anatomy and embryology Faculty of medicine ain shams university and AFCM armed force Collage of medicine.
7Associate Professor Biochemistry Department, Faculty of Science, Cairo University, Egypt.
8Associate professor of Biochemistry department Ain shams faculty of medicine
Abstract
Abstract
It is elevated proves that the polyphenolic compounds of natural origin, such as anthocyanins, being cyanidin-3-O-glucoside (Cy3G) one of the most widely distributed anthocyanins, may control ischemia/reperfusion (I/R) injury although how much sheltering occurs is not obvious. In the present study, the role of cyanidin-3-O-glucoside pretreatment of cardiac ischemia and dysfunction was studied. Cyanidin-3-O-glucoside in 3 doses (5, 10, and 15 mg/kg body weight), was introduced in vivo 5 min before a 45 min closure of the left anterior descending artery, followed by a 120 min reperfusion in male Wistar rats. Blood samples and cardiac tissue specimens were obtained for studying the cardiac markers and the expression of lncRNA-CTC-448F2.4, miR1273a, and mRNA-DCN (Decorin), Specimens of left ventricles were obtained and prepared for histopathological criteria. Specimens of pretreated rats showed minimal cardiac edema, hemorrhage, cellular inflammatory infiltration, and fibrosis in cardiac tissue samples. Notably, this protective administration of cyanidin-3-O-glucoside also produced a dose-dependent downregulation in lncRNA- CTC-448F2.4 and mRNA-DCN (Decorin, an important gene involved in the regulation of autophagy) with elevation in miR-1273a expressions. Cyanidin-3-O-glucoside pretreatment leads to improvements in cardiac function tests, enzymes, and myocytes. In conclusion, Cyanidin-3-O-glucoside is promising for the protection of the heart from injury following ischemia-reperfusion in the rat examination.
Keywords
Cyanidin-3-O-glucoside; epigenetic; ischemia/reperfusion (I/R) injury; Rat model
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