Tramadol Biological Effects, 2: Effective Therapeutic Efficacy of Lagenaria siceraria Preparation and Melatonin on Cell Biological, Histochemical and Histopathological Changes in Hepatocytes of Tramadol-Induced Male Mice | ||
| Egyptian Academic Journal of Biological Sciences, B. Zoology | ||
| Article 10, Volume 13, Issue 2, December 2021, Pages 105-119 PDF (1.35 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/eajbsz.2021.198263 | ||
| Author | ||
| Abdel-Baset M. Aref | ||
| -Cell Biology and Histochemistry Division, Zoology Department, Faculty of Science, South Valley University, Qena, Egypt. -Vice President of Institutional Animal Cure and Use Committee of South Valley University in Egypt (IACUC-SVU-Egypt). | ||
| Abstract | ||
| Goal: the present work aimed to study of biological effects of tramadol and treat its side effects via Lagenaria siceraria or melatonin. Results: Cytologically, histochemically, and histopathologically the present results showed the injection of tramadol for 20 and 40 days highly decreased the volume nuclei; DNA, RNA, total protein, and polysaccharides contents; and highly increased collagen content in normal hepatocytes of the male mice. Also, the present results showed the injection of tramadol showed a severe degree of histopathological changes in hepatocytes of the male mice. Cytologically histochemically, the present results showed that: the treatment via Lagenaria siceraria or melatonin pronounced increased the volume nuclei; DNA, RNA, and total protein contents; and pronounced decreased collagen content in tramadol-induced hepatocytes of the male mice. Also, Lagenaria siceraria pronounced increased polysaccharides content. The stopping tramadol modulatory increased RNA and total protein contents and decreased collagen content in tramadol-induced hepatocytes. Histopathologically, Lagenaria siceraria or melatonin displayed normal histological architecture and normal regeneration and division of the hepatocytesin the tramadol-induced male mice. Conclusion: tramadol induced various cytological, histochemical, and histopathological alterations, while the treatments resist and repair tramadol's side effects. | ||
| Keywords | ||
| Tramadol - Lagenaria Siceraria - Melatonin – Liver – Male Mice Cytologically; histochemically; and histopathologically | ||
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