LNC RNA HULC AS A NOVEL DIAGNOSTIC AND THERAPEUTIC TARGET IN PREECLAMPSIA | ||
| The Egyptian Journal of Biochemistry and Molecular Biology | ||
| Article 4, Volume 36, Issue 1, December 2018, Pages 65-78 PDF (419.22 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejb.2018.19852 | ||
| Authors | ||
| Omayma Abdelaleem* 1; Rania Mahmoud1; Olfat Shaker2; Nada Hemeda3; Naglaa Ahmed4 | ||
| 1Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Fayoum University | ||
| 2Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Cairo University. | ||
| 3Department of Genetics, Faculty of Agriculture, Fayoum University | ||
| 4Department of physiology, Faculty of Medicine, Zagazig University | ||
| Abstract | ||
| Background: Preeclampsia is a severe pregnancy-related disease mainly in developing countries. Non-coding RNAs are very important factors in regulating the expression of certain genes and are involved in pathogenesis of numerous diseases. Recently, non coding RNA biomarkers are used as diagnostic tools for different disorders such as PE. Methods: lnc RNA HULC expression levels was measured in serum collected from 22 patients with PE and 23 healthy pregnancies, using real-time PCR. Results: HULC expression was elevated reaching significant levels (p < 0.001with 2.16 fold change) in patients compared with control group. HULC was markedly increased in both severe and mild preeclamptic subgroups when compared to healthy controls (p<0.001 with 1.97 fold change and p<0.001 with 2.16 fold change respectively). ROC curve was assessed, the AUC of lnc RNA HULC was 0.952 (95%, CI=0.904 -1.000, P< 0.001). Conclusion: lnc RNA HULC may be involved in PE pathogenesis and may be used as potential non-invasive diagnostic biomarker for this disease. | ||
| Keywords | ||
| preeclampsia; lnc RNA HULC | ||
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