.Monier, N., Atteya, I., Askar, H., Helmy, S. (2020). Detection of the periodontal pathogen Porphyromonas Gingivalis in Oral Squamous Cell Carcinoma. test, 7(3), 24-28. doi: 10.21608/mjd.2020.198725
Nehad M .Monier; Islam M. Atteya; Hamdia Askar; Samah Helmy. "Detection of the periodontal pathogen Porphyromonas Gingivalis in Oral Squamous Cell Carcinoma". test, 7, 3, 2020, 24-28. doi: 10.21608/mjd.2020.198725
.Monier, N., Atteya, I., Askar, H., Helmy, S. (2020). 'Detection of the periodontal pathogen Porphyromonas Gingivalis in Oral Squamous Cell Carcinoma', test, 7(3), pp. 24-28. doi: 10.21608/mjd.2020.198725
.Monier, N., Atteya, I., Askar, H., Helmy, S. Detection of the periodontal pathogen Porphyromonas Gingivalis in Oral Squamous Cell Carcinoma. test, 2020; 7(3): 24-28. doi: 10.21608/mjd.2020.198725

Detection of the periodontal pathogen Porphyromonas Gingivalis in Oral Squamous Cell Carcinoma

Mansoura Journal of Dentistry
Article 5, Volume 7, Issue 3, September 2020, Pages 24-28    PDF (345.28 K)
Document Type: Original Article
DOI: 10.21608/mjd.2020.198725
Authors
Nehad M .Monier1; Islam M. Atteya2; Hamdia Askar3; Samah Helmy4
1Teaching assistant of oral medicine and periodontology, Faculty of Dentistry, Mansoura University, Egypt.
2Lecturer of Oral medicine and periodontology, Faculty of Dentistry, Mansoura University, Egypt.
3Professor of Medical Microbiology and Immunology, Faculty of Medicine, Mansoura University, Egypt.
4Professor of Oral medicine and periodontology, Faculty of Dentistry, Mansoura University, Egypt
Abstract
Background: The concept of infection-based carcinogenesis is gaining an increasing attention. Also periodontitis has been extensively studied as possible risk factor for gastrointestinal cancers including oral cancer.
Methodology: Using conventional PCR, we detected the presence of the key periodontal pathogen Porphyromonas gingivalis (P. gingivalis) in 25 oral cancer fresh tissue specimens versus 25 healthy oral mucosal tissue..
 
Results: P. gingivalis showed significantly higher prevalence in control group with slightly higher loads in cancer tissue. Bacterial presence was not found to be correlated with tumor progression.
Conclusion: P. gingivalis was not found to play a possible role in the cancerous lesion. More studies should be implemented to investigate the bacterial involvement in the oral tumors.
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