Role of rs 1800625 and 63bp deletion RAGE Gene Polymorphisms in Hepatocellular Carcinoma Progression | ||
| Egyptian Journal of Pure and Applied Science | ||
| Article 7, Volume 59, Issue 1, January 2021, Pages 20-28 PDF (454.32 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejaps.2021.81656.1001 | ||
| Authors | ||
| Mariam Mohamed* 1; Amal Ahmed2; Magdy Mohammed1; Marwa Hegazy1 | ||
| 1Biochemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt | ||
| 2Medical Research Division, National Hepatology and Tropical Medicine Research Institute, Cairo, Egypt | ||
| Abstract | ||
| Background: Hepatocellular carcinoma (HCC) is a common liver malignancy, whose heterogeneous occurrence indicates genetic dissimilarities between people in the main risk factors. Advanced glycation end product receptor (RAGE) is a multiligand receptor implicated in several pathogenic conditions, including cancer. In this study, the impact of RAGE gene polymorphisms on the susceptibility to hepatocarcinogenesis was explored. Aim of study: to estimate the effect of gene variations of RAGE on the progress of HCC caused by any viral infection and to examine the relationship between a RAGE and the risk and progression of HCC. Material and methods: single-nucleotide polymorphism (SNP; rs1800625) (-429T>C), and the 63 bp deletion (-407 to -345) in the 5’ flanking region of the RAGE gene were investigated among 90 HCV patients divided into 3 groups and 20 healthy controls. The HCV cases were diagnosed by polymerase chain reaction (PCR) while the HCC was diagnosed by Alfa-fetoprotein (AFP) test in addition to computed tomography. Liver cirrhosis was diagnosed with abdominal sonography. Results and conclusion: The study detected a significant association of rs1800625 with the increased risk of HCC also majority of HCC patient (86.7%) showed 63 bp deletion polymorphism (- 407 – 345 ) , our data suggest a correlation of RAGE gene polymorphism rs1800625 with the early stage of liver tumorigenesis and implicate its protective role in the progression of HCC. | ||
| Keywords | ||
| Hepatocellular carcinoma; Advanced glycation end product; Single nucleotide polymorphism | ||
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