Rageh, B., Tawfik, M., Abbas, O., Khalaf, A. (2022). Effects of Tripterygium wilfordii extracts on the hematological parameters of solid Ehrlich carcinoma bearing mice. test, 3(1), 74-87. doi: 10.21608/ajbas.2021.92698.1064
Basma Abdo Rageh; Mohammed Mahmoud Tawfik; Osama Ahmed Abbas; Ahmed Mohammed Khalaf. "Effects of Tripterygium wilfordii extracts on the hematological parameters of solid Ehrlich carcinoma bearing mice". test, 3, 1, 2022, 74-87. doi: 10.21608/ajbas.2021.92698.1064
Rageh, B., Tawfik, M., Abbas, O., Khalaf, A. (2022). 'Effects of Tripterygium wilfordii extracts on the hematological parameters of solid Ehrlich carcinoma bearing mice', test, 3(1), pp. 74-87. doi: 10.21608/ajbas.2021.92698.1064
Rageh, B., Tawfik, M., Abbas, O., Khalaf, A. Effects of Tripterygium wilfordii extracts on the hematological parameters of solid Ehrlich carcinoma bearing mice. test, 2022; 3(1): 74-87. doi: 10.21608/ajbas.2021.92698.1064

Effects of Tripterygium wilfordii extracts on the hematological parameters of solid Ehrlich carcinoma bearing mice

Alfarama Journal of Basic & Applied Sciences
Article 7, Volume 3, Issue 1, January 2022, Pages 74-87    PDF (671.13 K)
Document Type: Original Article
DOI: 10.21608/ajbas.2021.92698.1064
Authors
Basma Abdo Rageh1; Mohammed Mahmoud Tawfik2; Osama Ahmed Abbas3; Ahmed Mohammed Khalaf* 4
1Zoology department, Faculty of science, Portsaid University, Portsaid, Egypt
2Zoology department, Faculty of science, Port said University, Port said, Egypt
3Zoology Department, Faculty of Science, Port Said University, Port Said, Egypt.
4Department of Zoology, Faculty of Science, Port Said University
Abstract
The complete blood picture or count (CBC) and different hematological measurments are widely used in the assessment of many health problems such as cancer prognosis and progression. The roots of Chinese herb Tripterygium wilfordii (TW) is well-defined in Chinese alternative medicine since it is rich in a lot of beneficial components such as terpenoids, alkaloids and steroids. The intratumoral treatment with TW ethanolic and aqueous extracts individually and mix of them at a dose (16 mg/ kg) in Ehrlich ascites carcinoma (EAC) bearing mice had ameliorated the different hematological parameters such as red blood cell count (RBCs), hemoglobin concentration, white blood cells (WBCs) count and differential, as well as platelet count near normal values.
Treatment with cisplatin (2mg/kg) revealed many undesired hematological side effects like anemia, leukopenia and neutrophilia. Moreover, recently used inflamatory markers as prospective diagnostic parameters for cancer prognosis like monocyte lyphocyte ratio (MLR), neutrophil lymphocyte ratio (NLR), and platelet lymphocyte ratio (PLR) were decreased significantly after treatment with TW extracts.
In conclusion, treatment of EAC bearing mice with different extracts of TW could have anticancer activity regarding their remarked effect in improvement of distorted hematological parameters of the EAC bearing mice.
Keywords
Hematological parameters; EAC; Mice; Chinese herb Tripterygium wilfordii
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