M. El-Gohary, N., A. Ibrahim, M., Gabr, Y., Said, S. (2016). Synthesis and Antimicrobial Evaluation of Some Annulated Chromeno[2,3-b]Pyridines using 6-Methylchromone-3-Carbonitrile. test, 2(3), 28-34. doi: 10.18576/jpac/020308
Nasser M. El-Gohary; Magdy A. Ibrahim; Yassin Gabr; Sara Said. "Synthesis and Antimicrobial Evaluation of Some Annulated Chromeno[2,3-b]Pyridines using 6-Methylchromone-3-Carbonitrile". test, 2, 3, 2016, 28-34. doi: 10.18576/jpac/020308
M. El-Gohary, N., A. Ibrahim, M., Gabr, Y., Said, S. (2016). 'Synthesis and Antimicrobial Evaluation of Some Annulated Chromeno[2,3-b]Pyridines using 6-Methylchromone-3-Carbonitrile', test, 2(3), pp. 28-34. doi: 10.18576/jpac/020308
M. El-Gohary, N., A. Ibrahim, M., Gabr, Y., Said, S. Synthesis and Antimicrobial Evaluation of Some Annulated Chromeno[2,3-b]Pyridines using 6-Methylchromone-3-Carbonitrile. test, 2016; 2(3): 28-34. doi: 10.18576/jpac/020308

Synthesis and Antimicrobial Evaluation of Some Annulated Chromeno[2,3-b]Pyridines using 6-Methylchromone-3-Carbonitrile

Journal of Pharmaceutical and Applied Chemistry
Volume 2, Issue 3, September 2016, Pages 28-34    PDF (432.24 K)
Document Type: Original Article
DOI: 10.18576/jpac/020308
Authors
Nasser M. El-Gohary; Magdy A. Ibrahim; Yassin Gabr; Sara Said
Department of Chemistry, Faculty of Education, Ain Shams University, Roxy 11711, Cairo, Egypt.
Abstract
variety of heteroannulated chromeno[2,3-b]pyridines and their related compounds were efficiently synthesized from chemical transformations of 6-methylchromone-3-carbonitrile (1) with some cyclic and acyclic carbon nucleophiles. Also, the reactivity of carbonitrile 1 was studied towards 1-ethyl-4-hydroxy-3-nitroacetylquinolin-2(1H)-one (8) producing the unexpected 5-ethyl-10-methyl-8H-benzo[h]chromeno[2,3-b][1,6]naphthyridine-6(5H),8-dione (9). A diversity of 2-substituted-3-cyclohexyl-8-methyl-4H,6H-chromeno[3',2':5,6]pyrido[2,3-d]pyrimidine-4,6-diones were synthesized. Structures of the newly synthesized products have been deduced on the basis of elemental analysis and spectral data. The newly prepared compounds were screened for their antimicrobial activity.

Keywords
6-Methylchromone-3-carbonitrile; basic rearrangement; RORC; chromeno[2; 3-b]pyridines; chromeno[3'; 2':5; 6]pyrido[2; 3-d]pyrimidin
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