Neutrophil-Lymphocyte and Platelet-Lymphocyte ratios as a marker for diabetes control and complications. | ||
| Benha Medical Journal | ||
| Article 188, Volume 38, Issue 3, November and December 2021, Pages 984-995 PDF (825.78 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bmfj.2021.89950.1453 | ||
| Authors | ||
| amira mohamady Elsayed* 1; eman araby2 | ||
| 1department of internal medicine,faculty of medicine,Benha univeristy | ||
| 2department of Public Health and Community, Faculty of Medicine, Benha University, Egypt. | ||
| Abstract | ||
| Introduction: Hematological changes affecting the red blood cells, white blood cells, platelet function, and the coagulation factors were associated with diabetes mellitus (DM). The neutrophil-to-lymphocyte (N/L) and the platelet-to-lymphocyte (P/L) ratios, were offered as markers of inflammation in cardiac diseases, neoplasms and diabetes-related complications. Patients and Methods: A retrospective, cross sectional study of data from 200 patients with type 2 DM who attended the internal medicine clinic in Benha University Hospital. Clinical data were collected, including; age, sex, duration of DM, body mass index (BMI), micro-vascular and macro-vascular complications of DM. Laboratory data were collected in the form of glycosylated hemoglobin (HbA1c), fasting blood glucose (FBG),complete blood count with calculation of the N/L, and P/L ratios. The selected patients were divided into two groups; group I (good glycemic control, HbA1c ≤ 7 %) and group II (bad glycemic control, HbA1c ˃7). Results: Age was statistically insignificant between the two groups (p value of 0.341). HbA1c, BMI, and FBG were significantly higher in group II. A significant higher total leucocyte, neutrophil, and platelet counts in group II were noticed (p = 0.000). There were a significant higher N/L and P/L ratios in uncontrolled diabetics. Linear regression analysis revealed that age, FBG, neutrophil count, P/L and N/L ratios were significant independent parameters associated with HbA1c. Conclusion: The present study proposed that N/L& P/L ratios may be independently associated with poor blood glucose regulation in patients with type 2 DM. Furthermore, diabetic complications were associated with higher N/L & P/L ratios. | ||
| Keywords | ||
| Neutrophil-Lymphocyte ratio; and Platelet-Lymphocyte ratio; diabetes control | ||
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