EFFECT OF METHOMYL AND IMIDACLOPRID ON LIVER AND KIDNEY FUNCTIONS IN MALE ALBINO RATS | ||
| Journal of Soil Sciences and Agricultural Engineering | ||
| Article 7, Volume 32, Issue 6, June 2007, Pages 5009-5018 PDF (972.84 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jssae.2007.201302 | ||
| Authors | ||
| M .H. Salem1; M. Saad1; Olfat A. Radwan2; Naglaa K. Younes2 | ||
| 1Department of biochemistry- Faculty of agriculture , Cairo University | ||
| 2Central Agricultural Pesticides laboratory , Agricultural Research Center , Dokki ,Giza | ||
| Abstract | ||
| The effect of daily oral administration of Carbamate ( Methomyl) ,at 0.2 , 2 and 5 mg/kg b.w and neonicotiniod ( Imidacloprid ), at 0.5 ,1 and 5 mg/kg b.w insecticides on male albino rats for 28 successive days, followed by 15 days recovery were studied . The most important biochemical parameters of the serum ; alanine aminotranseferase ( ALT) , aspartate aminotraseferase (AST) ,alkaline phosphatase activities ( ALP ) , total protein , protein profile (albumin and globulin) , urea , creatinine were investigated . The activities of AST ,ALT were significantly increased at all tested times in cumulatively dose related manner .No significant changes were observed in alkaline phosphatase enzyme activity compared with the control. On the other hand serum total protein , Protein Profile (albumin and globulin ) recorded highly significant decrease in all treatments with Methomyl and imidacloprid . A highly significant increases in the blood urea and creatinine with two tested insecticides in the following order ,methomyl and imidacloprid. after treatments 14 days were observed . The levels were decreased during the 21, 28 and 45 days. | ||
| Keywords | ||
| imidacloprid; methomyl; rats; Liver; Kidney | ||
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