Seropostivity of Toxoplasma gondii in Children with Bronchial Asthma at Benha University Hospital,Egypt | ||
| Zagazig University Medical Journal | ||
| Article 862, Volume 28, Issue 5, September 2022, Pages 1164-1168 PDF (307.25 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/zumj.2021.93142.2331 | ||
| Authors | ||
| Akram Elshafey Elsadek1; Maysa Ahmed Eraky2; Mona Abd Elwahab ElBishry1; basma fathy mohamed3; asmaa elkholy* 4 | ||
| 1Pediatric Department, Faculty of Medicine, Benha University ,Benha,Egypt. | ||
| 2Parasitology Department, Faculty of Medicine, Benha University, Benha,Egypt. | ||
| 3Pediatric Department, Benha Fever Hospital, Benha,Egypt | ||
| 4parasitology department,faculty of medicine, Banha university,Banha ,Egypt. | ||
| Abstract | ||
| Abstract: Background: Bronchial asthma is the most frequent chronic disease in children. Asthma exacerbation is a leading cause of pediatric morbidity and hospitalization, and children's social and emotional lives. Toxoplasma gondii (T. gondii) has been linked to a lower prevalence of allergy illness and has been regarded as a measure of poor hygiene. Microbe-induced Th1 cytokines such as gamma interferon have been postulated to mediate the protective impact of microbial exposure. The goal of the study was to investigate imaginable association between T. gondii infection and asthma in children. Methods: A comparative case control study was conducted on patients at Benha University Hospital's Pediatric Department and Allergy & Asthma clinic from October 2016 to October 2017. This study included 105 children (35 with resistant bronchial asthma, 35 with responsive bronchial asthma, and 35 healthy control children). They were tested for anti-T. gondii IgG seropositivity using ELISA. Results: Our results showed that only two patients (5.7%) of 35 were positive for Toxoplasma in the resistant asthmatic group. Still, four patients (11.4%) of 35 among the responsive asthma group were positive, while nine patients (25.7%) of 35 in the control group were positive for T.gondii IgG. Conclusion: Our findings show a link between Toxoplasma infection and reduced allergy symptoms in the groups investigated. Infection with T.gondii may help prevent bronchial asthma from developing. | ||
| Keywords | ||
| Key words: Toxoplasma; children; bronchial asthma | ||
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