Bakhshwan, S., Hamed, H., Marzouk, M., Hanna, M. (2009). Some investigations on the clinical and biochemical alterations associated with dizinon toxicity in Clarias gariepinus. test, 13(2), 173-197. doi: 10.21608/ejabf.2009.2039
Safinaz Bakhshwan; Heba Hamed; Mohamed Marzouk; Magdy Hanna. "Some investigations on the clinical and biochemical alterations associated with dizinon toxicity in Clarias gariepinus". test, 13, 2, 2009, 173-197. doi: 10.21608/ejabf.2009.2039
Bakhshwan, S., Hamed, H., Marzouk, M., Hanna, M. (2009). 'Some investigations on the clinical and biochemical alterations associated with dizinon toxicity in Clarias gariepinus', test, 13(2), pp. 173-197. doi: 10.21608/ejabf.2009.2039
Bakhshwan, S., Hamed, H., Marzouk, M., Hanna, M. Some investigations on the clinical and biochemical alterations associated with dizinon toxicity in Clarias gariepinus. test, 2009; 13(2): 173-197. doi: 10.21608/ejabf.2009.2039

Some investigations on the clinical and biochemical alterations associated with dizinon toxicity in Clarias gariepinus

Egyptian Journal of Aquatic Biology and Fisheries
Article 11, Volume 13, Issue 2, April 2009, Pages 173-197    PDF (232.16 K)
Document Type: Original Article
DOI: 10.21608/ejabf.2009.2039
Authors
Safinaz Bakhshwan1; Heba Hamed1; Mohamed Marzouk2; Magdy Hanna2
1Department of Zoology, Girls college for Arts, Science & Education, Ain Shams University, Egypt.
2Department of Fish Diseases and Management, Faculty of Veterinary Medicine, Cairo University, Egypt.
Abstract
Diazinon is widely and effectively used in agriculture as well as in domestic and aquaculture aspects. As a result of its widespread application, its ecotoxicity study is needed to determine its effects on the aquatic organisms and
its potential impact as an environmental contaminant. In this study, the half lethal concentration (LC50) of diazinon for Clarias gariepinus was calculated. Diazinon toxicity was evaluated through acute and chronic exposures of fish to
1/2 and 1/10 the calculated LC50 for 1w & 6 w respectively. Results showed that the LC50 /96h was 5.98 ppm. The effects of both acute and chronic exposures revealed clinical abnormalities in the form of nervous and respiratory disorders manifested by erratic swimming and/or circling, rapid opercular movements and abnormal skin pigmentation that appeared in the form of skin fading. A significant increase in cortisol, glucose, AST & ALT activities, urea, uric acid,
creatinine and serum Ca++ levels were recorded. Furthermore, diazinon exposures were associated with an inhibition of cholinesterase activity, a decrease in total protein concentration in serum with a reduction in both albumin
and globulin. This study declared that diazinon is an extremely toxic organophosphate pesticide for C. gariepinus, its improper application often results in contamination of the environment and consequently in deleterious health effects. So, strict precautions should be followed.
Keywords
Diazinon; Clinical signs; biochemical parameters; residues
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