Assessment of The Diagnostic Value of TOX Versus CD3 Immunohistochemical Markers in Detection of Early Mycosis Fungoides Cases | ||
| The Egyptian Journal of Hospital Medicine | ||
| Article 54, Volume 85, Issue 2, October 2021, Pages 3778-3782 PDF (573.07 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejhm.2021.204575 | ||
| Authors | ||
| Mai Ahmed Gobran* ; Ahmed Embaby; Abeer Hafeez | ||
| Abstract | ||
| Background: Primary cutaneous lymphoma (PCL) with clonal proliferation of atypical CD4+ skin-homing T lymphocyte cells is called Mycosis Fungoides (MF). TOX staining is observed in subtypes of PCL, as MF & Sézary Syndrome (SS) in comparison to controls. Early MF is difficult to diagnose, & its distinction from inflammatory diseases may be impossible. Objective: This study aimed to evaluate the expression of the TOX versus CD3 as a diagnostic marker for early MF. Patients and methods: retrospective-cross sectional study includes 30 MF and 30 benign cutaneous inflammatory diseases (BCID) cases. All were evaluated using H & E and immunohistochemical staining for TOX & CD3. Results: There was statistically significant increase of TOX & CD3 expression in MF than BCID & ability of TOX to detect all true positive cases (100.0%) compared to (76.7%) for CD3, (P < 0.001). Conclusion: TOX had the highest sensitivity (100.0%) & accuracy (88.3%). TOX is useful marker in the diagnosis of early MF & differentiating it from BCID. | ||
| Keywords | ||
| TOX; CD3; Mycosis Fungoides; Benign cutaneous inflammatory diseases (BCIDs); Immunohistochemistry | ||
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