Egela, S., Abed El-Hamid, Y., elazab, T., El sayed, B., mahgoub, M. (2021). Musculoskeletal Manifestations and Bone Mineral Density in Chronic Hepatitis C Patients. test, 38(3), 848-864. doi: 10.21608/bmfj.2021.42594.1316
samy Egela; Yasser Abed El- Aziz Abed El-Hamid; tamer eleraky elazab; Basma Goda El sayed; marwa mahgoub. "Musculoskeletal Manifestations and Bone Mineral Density in Chronic Hepatitis C Patients". test, 38, 3, 2021, 848-864. doi: 10.21608/bmfj.2021.42594.1316
Egela, S., Abed El-Hamid, Y., elazab, T., El sayed, B., mahgoub, M. (2021). 'Musculoskeletal Manifestations and Bone Mineral Density in Chronic Hepatitis C Patients', test, 38(3), pp. 848-864. doi: 10.21608/bmfj.2021.42594.1316
Egela, S., Abed El-Hamid, Y., elazab, T., El sayed, B., mahgoub, M. Musculoskeletal Manifestations and Bone Mineral Density in Chronic Hepatitis C Patients. test, 2021; 38(3): 848-864. doi: 10.21608/bmfj.2021.42594.1316

Musculoskeletal Manifestations and Bone Mineral Density in Chronic Hepatitis C Patients

Benha Medical Journal
Article 5, Volume 38, Issue 3, November and December 2021, Pages 848-864    PDF (1.02 M)
Document Type: Original Article
DOI: 10.21608/bmfj.2021.42594.1316
Authors
samy Egela1; Yasser Abed El- Aziz Abed El-Hamid1; tamer eleraky elazab2; Basma Goda El sayed* 3; marwa mahgoub4
1Professor of Rheumatology, Rehabilitation and physical medicine Faculty of Medicine, Benha University
2hepatology,gastroentrology and infectious disease
3MB.B.Ch. (2012) Faculty of Medicine – El menofiya University
4Assistant professor of Rheumatology, Rehabilitation and physical medicine Faculty of Medicine, Benha University
Abstract
Background: many extrahepatic manifestations including auto-immune, rheumatic disease and metabolic bone impairment have been stated in chronic hepatitis C virus (HCV) infected patients. Direct antiviral agents (DAAs) are major developments in the treatment of HCV infection and were reported to have effect on the musculoskeletal manifestations.

Objectives: to evaluate the effect of chronic hepatitis C and direct antiviral agents (DAAs) on musculoskeletal system, bone mineral density (BMD).
Methods: the current study involved sixty patients with chronic hepatitis c, thirty patients with no history of anti-viral agent’s treatment (group I) and the other patients achieved response on DAAs within the last one year (group II). All patients were subjected to history taking, physical examination, investigations including (calcium, Phosphorus, Parathormone hormone, alkaline phosphatase and vitamin D) and DEXA scan for BMD measurement.
Results: In this study, group I showed significantly lower Bone mineral density compared to group II. The frequency of musculoskeletal manifestations caused by HCV in group I is higher than group II including; arthralgia (70%), sicca symptoms (50%), fatigue (40%), fibromyalgia (20%), arthritis and cryoglobinemic vasculitis (10%).
Conclusion: Musculoskeletal manifestations including decreased BMD are frequent in CHC patients and treatment with DAAs proved a beneficial impact.
Keywords
Chronic chronic hepatitis C; Musculoskeletal manifestations; Bone mineral density; DAAs
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