The Effect of Laparoscopic Sleeve Gastrectomy on Adiponectin Level | ||
| Egyptian Journal of Chemistry | ||
| Article 51, Volume 65, Issue 5, May 2022, Pages 529-536 PDF (330.05 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejchem.2021.96584.4530 | ||
| Authors | ||
| Hisham A. AbouEisha1; AbdElRahman M. Mohamed2; Mohammed A Daoud* 3; Ahmed Abd Alsalam4; Tarek A. Ramzy1; Mohamed D. Sarhan4 | ||
| 1M.D | ||
| 2MSC,MRCS | ||
| 3FRCSEd,MD,FEBS,MRCS,MSc | ||
| 4M.D,MRCS,MSc | ||
| Abstract | ||
| Background: Obesity is accompanied with chronic low‐grade inflammation contributing to obesity‐related diseases. Sleeve Gastrectomy(SG) has been shown to be a very effective solo option for long‐term weight loss and control of obesity‐associated morbidity. Objective: measuring Adiponectin ,c-reactive protein (CRP),erythrocyte sedimentation rate (ESR),total leucocytes count (TLC) and hemoglobin A1C(HbA1C) before and after 4 months of SG to assess the effect of sleeve on the inflammatory profile of these patients. Settings: one bariatric center Kasr Al-Ainy teaching Hospital in Egypt Patients and Methods: a prospective study included 40 patients who underwent a laparoscopic sleeve gastrectomy (SG).Preoperative and 4 months postoperative Adiponectin, CRP, ESR,TLC and HbA1C levels were measured, the results were documented and analyzed then the results were correlated to the baseline results and to change in body mass index (BMI). Results: Baseline tendency towards inflammation in our patients was represented with elevated mean CRP, ESR1and ESR2, high normal mean TLC and decreased mean Adiponectin. 4 months after sleeve, mean adiponectin level rose from 1.16 mg/L preoperatively to 1.55 mg/L postoperatively, mean CRP dropped from 13.43 mg / L to 6.18 mg/L, mean ESR1 and ESR2 dropped from 33.97 mm / hr and 59.83 mm / hr to 23.27 mm / hr and 45.08 mm / hr respectively and mean TLC dropped from 7.86 103 / cm to 6.27 103/cm. Conclusion: Obese patients have baseline low grade inflammation. SG causes significant improvement of obesity related inflammation on the short term, the effect derived by SG on improving inflammatory markers is not totally dependent on reduction of BMI. | ||
| Keywords | ||
| morbid obesity; sleeve gastrectomy; adiponectin; obesity related inflammatory status; CRP; ESR; TLC | ||
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