Mirzaali, M., Yuzugulen, J., Amiriani, T., Marjani, M., Marjani, A. (2021). EFFECT OF DIFFERENT DOSES OF METFORMIN TABLETS ON METABOLIC SYNDROME COMPONENETS IN WOMEN WITH TYPE 2 DIABETES MELLITUS IN GORGAN (SOUTH EAST OF CASPIAN SEA). test, 44(2), 443-453. doi: 10.21608/bfsa.2021.207167
Mona Mirzaali; Jale Yuzugulen; Taghi Amiriani; Majid Marjani; Abdoljalal Marjani. "EFFECT OF DIFFERENT DOSES OF METFORMIN TABLETS ON METABOLIC SYNDROME COMPONENETS IN WOMEN WITH TYPE 2 DIABETES MELLITUS IN GORGAN (SOUTH EAST OF CASPIAN SEA)". test, 44, 2, 2021, 443-453. doi: 10.21608/bfsa.2021.207167
Mirzaali, M., Yuzugulen, J., Amiriani, T., Marjani, M., Marjani, A. (2021). 'EFFECT OF DIFFERENT DOSES OF METFORMIN TABLETS ON METABOLIC SYNDROME COMPONENETS IN WOMEN WITH TYPE 2 DIABETES MELLITUS IN GORGAN (SOUTH EAST OF CASPIAN SEA)', test, 44(2), pp. 443-453. doi: 10.21608/bfsa.2021.207167
Mirzaali, M., Yuzugulen, J., Amiriani, T., Marjani, M., Marjani, A. EFFECT OF DIFFERENT DOSES OF METFORMIN TABLETS ON METABOLIC SYNDROME COMPONENETS IN WOMEN WITH TYPE 2 DIABETES MELLITUS IN GORGAN (SOUTH EAST OF CASPIAN SEA). test, 2021; 44(2): 443-453. doi: 10.21608/bfsa.2021.207167

EFFECT OF DIFFERENT DOSES OF METFORMIN TABLETS ON METABOLIC SYNDROME COMPONENETS IN WOMEN WITH TYPE 2 DIABETES MELLITUS IN GORGAN (SOUTH EAST OF CASPIAN SEA)

Bulletin of Pharmaceutical Sciences Assiut University
Article 15, Volume 44, Issue 2, December 2021, Pages 443-453    PDF (621.13 K)
Document Type: Original Article
DOI: 10.21608/bfsa.2021.207167
Authors
Mona Mirzaali1; Jale Yuzugulen1; Taghi Amiriani2; Majid Marjani* 1; Abdoljalal Marjani* 3
1Faculty of Pharmacy, Eastern Mediterranean University, 99628, Famagusta, North Cyprus via Mersin 10, Turkey
2Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran
3Metabolic disorders research center, Biochemistry and Biophysics department, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Golestan Province, Iran.
Abstract
Studies on oral anti-hyperglycemic drugs have been shown in some studies to help and
treat type 2 diabetic patients. The present study was designed to evaluate and compare the
effect of different doses of metformin tablets on metabolic syndrome components in type 2
diabetic women in Gorgan, South East of Caspian Sea.Forty type 2 diabetic patients received
500 mg/day and 1000 mg/day metformin tablets for 12 months and forty healthy women were
included in this study. The ATP III criteria were used to determine metabolic syndrome
components, and lipid profiles, HbA1c and insulin were measured. Significant differences were
found between blood sugar, triglycerides, high-density lipoprotein (HDL)-cholesterol,
hemoglobin A1c (HbA1c) and insulin of the patients received 500 mg/day and 1000 mg/day
metformin monotherapy. The blood sugar, triglycerides and insulin were significantly lower in
patients received 500 and 1000 mg/day metformin than control groups. In both groups, HDL-
cholesterol was higher than control groups, but HbA1c was significantly higher and lower in
patients received 500 and 1000 mg/day metformin than control groups, respectively. In both
study groups, positive significant correlation was found between blood glucose and HbA1c and,
blood glucose and triglyceride levels. Our study showed the efficacy of the 1000 mg/day
metformin monotherapy on better control of blood sugar, HbA1c, triglyceride and HDL-
cholesterol levels, but Metformin had no effect on waist circumference and blood pressure.
Treatment with this dose of metformin may be more beneficial for type 2 diabetic patients than
those other doses.
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