NEURAL STEM CELLS AS A PROMISING THERAPEUTIC APPROACH IN NEUROLOGICAL DISEASES | ||
| Bulletin of Pharmaceutical Sciences Assiut University | ||
| Article 20, Volume 44, Issue 2, December 2021, Pages 525-536 PDF (678.7 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bfsa.2021.207179 | ||
| Author | ||
| Rawaa Al-Mayyahi* | ||
| Department of laboratory and clinical Sciences, College of Pharmacy, University of Basrah, Basrah, Iraq | ||
| Abstract | ||
| The central nervous system lacks the ability to undergo neuronal regeneration. Neurological diseases such as neurotrauma and neurovascular diseases impact many people around the world. Neural stem cell-based treatment for neurological diseases limits clinical damage by providing and by regeneration local support for damaged and lost neural cells. Neural stem cells (NSCs) have a vital role in cell therapy as they can give rise to neurons or glial cells and repair neurological injuries. NSCs were able to secrete constitutively neuroprotective factors that have an important role in neurological repair. Moreover, upon transplantation, NSCs were shown capable of migration into lesioned sites and improved functional recovery after neurological diseases due to their important role in neurogenesis, immunomodulation, and brain plasticity. This review focuses on the roles of NSCs-based therapies in neurological diseases and summarise current advancements in NSC transplantation into rodent models of neurological disorders as well as shed the light on the progress of NSCs therapies in clinical trials. | ||
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