Design, synthesis, molecular docking study and toxicological evaluation potential of new spiro and fused heterocycles against agricultural insect pests | ||
| Egyptian Journal of Chemistry | ||
| Article 21, Volume 65, Issue 6, June 2022, Pages 207-218 PDF (1.14 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejchem.2021.100429.4705 | ||
| Authors | ||
| Salwa S. Abdelwahab* 1; Sameh A. Rizk2; Ahmed M. Eid3 | ||
| 1Faculty of Pharmacy, Future University in Egypt, New Cairo 11835, Egypt, | ||
| 2Chemistry Department, Science Faculty, Ain Shams University, Cairo, Egypt 11566 | ||
| 3Chemistry section, School od distance education, University Sains Malaysia, Penang, Malaysia | ||
| Abstract | ||
| Reactions of 4'-(2-oxo-3-(thiophen-2-ylmethylene)furan-5-yl)acetanilide with amines, carbon nucleophiles and isatin, under various conditions provided a variety of spiro-, fused- and heteocyclic deivatives. The structures of the new compounds were characterized by spectral data and elemental analysis. The larvicidal activities of the synthesized compounds were tested against Plutella xylostella and Helicoverpa armigera larvae in vitro. The molecular docking simulations results towards acetylcholinesterase of Drosophila Melanogaster demonstrated the role of the new compounds as prominent larvicides. | ||
| Keywords | ||
| furanone; pyrrolone; spiroxyindoline; dihydropyridazine; Plutella xylostella; Helicoverpa armigera | ||
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