Eissa, M., Mohammed, L., Malik, H., Khalil, A., Ibrahim, N., Abdelazem, A., Said, N. (2021). Vitamin D Receptor Gene (Fok-I) Polymorphisms in Type 1 Diabetic Children; Case Study in Zagazig University Hospitals. test, 85(2), 4223-4226. doi: 10.21608/ejhm.2021.208091
Mohamed Eissa; Lamia A Mohammed; Hany Abdel Malik; Azza Ali Khalil; Nahla Ibrahim; Abdallah Salem Abdelazem; Nora M. Said. "Vitamin D Receptor Gene (Fok-I) Polymorphisms in Type 1 Diabetic Children; Case Study in Zagazig University Hospitals". test, 85, 2, 2021, 4223-4226. doi: 10.21608/ejhm.2021.208091
Eissa, M., Mohammed, L., Malik, H., Khalil, A., Ibrahim, N., Abdelazem, A., Said, N. (2021). 'Vitamin D Receptor Gene (Fok-I) Polymorphisms in Type 1 Diabetic Children; Case Study in Zagazig University Hospitals', test, 85(2), pp. 4223-4226. doi: 10.21608/ejhm.2021.208091
Eissa, M., Mohammed, L., Malik, H., Khalil, A., Ibrahim, N., Abdelazem, A., Said, N. Vitamin D Receptor Gene (Fok-I) Polymorphisms in Type 1 Diabetic Children; Case Study in Zagazig University Hospitals. test, 2021; 85(2): 4223-4226. doi: 10.21608/ejhm.2021.208091

Vitamin D Receptor Gene (Fok-I) Polymorphisms in Type 1 Diabetic Children; Case Study in Zagazig University Hospitals

The Egyptian Journal of Hospital Medicine
Article 127, Volume 85, Issue 2, October 2021, Pages 4223-4226    PDF (614.48 K)
Document Type: Original Article
DOI: 10.21608/ejhm.2021.208091
Authors
Mohamed Eissa* ; Lamia A Mohammed; Hany Abdel Malik; Azza Ali Khalil; Nahla Ibrahim; Abdallah Salem Abdelazem; Nora M. Said
KSA, Abha, 61412, P.O. Box 641
Abstract
Background: Many meta-analyses studied the association between vitamin D receptor (VDR) gene polymorphism and type 1 diabetes (T1DM) susceptibility. Objective: This study was designed to assess the role of VDR gene (FOK-I) polymorphisms in type 1 diabetic children from Zagazig University Hospitals in Egypt.  Patients and Method: In this case-control study, the genotypes of VDR gene (FOK-I) polymorphisms were assessed in 180 type 1 diabetic children and 120 healthy matched age controls by PCR-RFLP analysis. Results: Ahigh statistical difference between patient and control regarding VDR gene (FOK-I) polymorphisms, where 44% of the patient group had heterozygous genotype (AG) compared to 8.3% in the control group. AG genotype has almost a higher risk nine times odds ratio (OR) = 8.8 than AA genotype in diabetic patients. There was a significant increase in the G allele in the patient group. Moreover, a significant association between (FOK-I) polymorphisms and T1DM complications was also observed.
Conclusion: (AG) genotype of VDR gene (FOK-I) polymorphisms could be a risk factor for T1DM complications. So, VDR gene (FOK-I) polymorphisms should be performed with other genetic studies for early prediction, detection and prevention of microvascular complications of T1DM that adversely affect health-related quality of life of Egyptian children and burden the primary care units.
 
Keywords
FOK-I; Genotype; Polymorphisms; T1DM; VDR gene
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