The role of lepidium sativum seed and boswellia carterii polar extracts in ameliorating blood glucose, lipid profile, iron status, immune system and cardiac and hepatic pathology in rat model of diabesity | ||
| Egyptian Journal of Chemistry | ||
| Article 31, Volume 65, Issue 7, July 2022, Pages 313-326 PDF (386.53 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejchem.2021.103599.4805 | ||
| Authors | ||
| Sahar Y. Al-Okbi* 1; Hagar Farid H. Elbakry2; Shaimaa E. Mohammed3; Thanna E. Hamed4; Asmaa A. Ramadan5 | ||
| 1Department of Nutrition and Food Sciences, National Research Centre, Cairo, Egypt | ||
| 2Nutrition and Food Sciences Dept., National Research Centre, Dokki, Cairo, Egypt. | ||
| 3Nutrition and Food Sciences Department, National Research Centre, Dokki, Cairo, Egypt | ||
| 4Nutrition and Food Sciences Department, National Research Centre, Egypt | ||
| 5Nutrition and Food Sciences Department, National Research Centre, Cairo, Egypt | ||
| Abstract | ||
| Diabesity, a combined diabetes and obesity, is a worldwide illness in the 21 century. The aim of the present research was to study blood glucose, lipid profile, iron status, immune system and cardiac and hepatic pathology in diabesity rat model and the potential protection by neutraceuticals. Dietary obesity and diabetes were simultaneously induced in rats as model of diabesity. Three nutraceuticals were tested (Lepidium sativum seed ethanol and water extracts and Boswellia carterii water extract). Biochemical analysis of blood and histopathological examination of liver and heart were carried out. Phenolic and flavonoidal contents were determined in Lepidium sativum seed and Boswellia carterii. Results showed iron deficiency, dyslipidemia and significantly elevated interleukin 6, blood glucose and malondialdehyde, in addition to alteration in the histopathology of liver and heart in the diabesity control (DOC) group compared to the NC group. Treatment with the different nutraceuticals produced variable improvement compared to the DOC group. Lepidium sativum seed showed higher phenolic and flavonoidal contents than Boswellia carterii (p ≤ 0.05). Lepidium sativum ethanol extract was superior in improving dyslipidemia, inflammation and oxidative stress while Boswellia carterii water extract was the most anti-hyperglycemic. Lepidium sativum seed water extract showed the best improvement in iron status. | ||
| Keywords | ||
| High fat-high sucrose diet; diabesity; iron status; plasma lipids; interleukin-6; liver pathology; heart pathology. | ||
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