Abd Elghany, F., Algharabawy, E., Shehatah, A., Elal, I. (2021). Chemerin Level in the Serum of Knee Osteoarthritis Patients and its Relation to Disease Severity. test, 85(2), 4279-4283. doi: 10.21608/ejhm.2021.209052
Fadia A. Abd Elghany; Eman S. Algharabawy; Aziza B. Shehatah; Ibrahim T. Abd Elal. "Chemerin Level in the Serum of Knee Osteoarthritis Patients and its Relation to Disease Severity". test, 85, 2, 2021, 4279-4283. doi: 10.21608/ejhm.2021.209052
Abd Elghany, F., Algharabawy, E., Shehatah, A., Elal, I. (2021). 'Chemerin Level in the Serum of Knee Osteoarthritis Patients and its Relation to Disease Severity', test, 85(2), pp. 4279-4283. doi: 10.21608/ejhm.2021.209052
Abd Elghany, F., Algharabawy, E., Shehatah, A., Elal, I. Chemerin Level in the Serum of Knee Osteoarthritis Patients and its Relation to Disease Severity. test, 2021; 85(2): 4279-4283. doi: 10.21608/ejhm.2021.209052

Chemerin Level in the Serum of Knee Osteoarthritis Patients and its Relation to Disease Severity

The Egyptian Journal of Hospital Medicine
Article 137, Volume 85, Issue 2, October 2021, Pages 4279-4283    PDF (643.13 K)
Document Type: Original Article
DOI: 10.21608/ejhm.2021.209052
Authors
Fadia A. Abd Elghany; Eman S. Algharabawy; Aziza B. Shehatah; Ibrahim T. Abd Elal
Abstract
Background: Chemerin is a new adipokine that has been linked to joint inflammation and degeneration. It has a pro-inflammatory effect and modulates immune system activity.
Objective: The aim of the work was to assess the chemerin role in diagnosis as well as monitoring of severity of the disease in knee osteoarthritis (KOA) patients.
Patients and Methods: This case-control study included a total of 60 subjects, 30 of them had knee osteoarthritis (KOA) and 30 served as controls, attending at Department of Rheumatology, Rehabilitation, and Physical Medicine, Zagazig University Hospitals. Chemerin level was measured for all the subjects by ELISA technique. In osteoarthritis group, knee osteoarthritis was assessed using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC).
Results: Statistically insignificant differences in age, BMI, as well as sex were found among the 2 studied groups.Serum chemerin levels in patients with KOA were statistically significantly higher than in controls, with a p-value of 0.001. Serum chemerin had no statistically significant correlations to age, BMI, or length of illness, while WOMAC scores, CRP, as well as ESR were strongly associated with serum chemerin levels.
Conclusion: It could be concluded that serum chemerin can be utilized as an inflammatory marker in KOA patients and it can be considered as a therapeutic target. Further studies are recommended to assess its levels in other types of OA, and other rheumatic diseases.
 
Keywords
Chemerin; Knee osteoarthritis; Disease severity
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