Jafari, S., Nabavizadeh, F., Vahedian, J., Ardestani, M., Samandari, H., Mehrjerdi, A. (2019). Targeted drug delivery of capecitabine to mice xenograft gastric cancer by PAMAM dendrimer nanocarrier. test, 2(1), 30-55. doi: 10.52378/fkh195276
Sharareh Jafari; Fatemeh Nabavizadeh; Jalal Vahedian; Mehdi Shafie Ardestani; Hedayat Samandari; Ali Zare Mehrjerdi. "Targeted drug delivery of capecitabine to mice xenograft gastric cancer by PAMAM dendrimer nanocarrier". test, 2, 1, 2019, 30-55. doi: 10.52378/fkh195276
Jafari, S., Nabavizadeh, F., Vahedian, J., Ardestani, M., Samandari, H., Mehrjerdi, A. (2019). 'Targeted drug delivery of capecitabine to mice xenograft gastric cancer by PAMAM dendrimer nanocarrier', test, 2(1), pp. 30-55. doi: 10.52378/fkh195276
Jafari, S., Nabavizadeh, F., Vahedian, J., Ardestani, M., Samandari, H., Mehrjerdi, A. Targeted drug delivery of capecitabine to mice xenograft gastric cancer by PAMAM dendrimer nanocarrier. test, 2019; 2(1): 30-55. doi: 10.52378/fkh195276

Targeted drug delivery of capecitabine to mice xenograft gastric cancer by PAMAM dendrimer nanocarrier

African Journal of Gastroenterology and Hepatology
Article 3, Volume 2, Issue 1, February 2019, Pages 30-55    PDF (747.04 K)
Document Type: Original Clinical
DOI: 10.52378/fkh195276
Authors
Sharareh Jafari1, 2; Fatemeh Nabavizadeh* 2; Jalal Vahedian3; Mehdi Shafie Ardestani4; Hedayat Samandari1; Ali Zare Mehrjerdi5
1Electrophysiology Research Center, Neurosciences Institute, Tehran University of Medical Sciences, Tehran, Iran
2Department of Physiology, Medical school, Tehran University of Medical Sciences, Tehran, Iran
3Department of Surgery, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran
4Department of Radiopharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
5Department of Pathology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran
Abstract
Aims:
This study used an animal xenograft model of gastric cancer induction to investigate the therapeutic effects of capecitabine polyamidoamine (PAMAM) dendrimer complex against cancer and its potential side effects.
Methods and Materials:
Human gastric cancer tissue was obtained from patients with gastric carcinoma and transplanted into mice. Anticancer drug capecitabine was loaded into PAMAM dendrimer nano-carrier and injected into the animals. All animals received cyclosporine before the surgery.
Results:
Capecitabine-dendrimer complex reduced the size of the axillary implanted tumor, the levels of AST and ALP, and the drug-induced adverse effects on other body organs. Furthermore, it increased apoptotic and necrotic responses in the grafted tumor, RBC, WBC, and platelet counts compared to free capecitabine.
Conclusions:
In gastric cancer settings, the PAMAM dendrimer drug delivery method effectively improved therapeutic index and outcomes and reduced undesirable side-effects of the capecitabine.
Keywords
Gastric cancer; Xenograft; Capecitabine; Cyclosporine; Poly amidoamine dendrimer (PAMAM); Mice
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