Mycosis Fungoides Diagnosis Using TOX Versus Old Panel Immunohistochemical Markers | ||
| The Egyptian Journal of Hospital Medicine | ||
| Article 147, Volume 85, Issue 2, October 2021, Pages 4331-4337 PDF (1.19 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejhm.2021.209428 | ||
| Authors | ||
| Mai Ahmed Gobran* ; Mohamed Ali Alabiad; Abeer Hafeez; Sabah Mohamed Hanafy; Amira Salem | ||
| Abstract | ||
| Background: For primary cutaneous lymphoma, mycosis fungoides (MF) is the most prevalent form with skin-homing T cells plus clonal proliferation of CD4. In many CTCLs, thymocyte selection associated with the HMG-box (TOX) is an uncontrolled gene, together with MF in comparison with controls. Early mycosis fungoides is difficult to diagnose, and, its distinction from inflammatory diseases is sometimes impossible. Objective: In this study, we compared the TOX vs C7 and CD4 expression as an early mycosis fungoides diagnostic markers & to assess their ability to differentiate Mycosis fungoides from benign cutaneous inflammatory diseases (BCID). Materials and methods: 60 patients who had been previously diagnosed as MF (30 cases) and BCID (30 cases). All were evaluated histopathologically using H & E and immunohistochemically staining for TOX, CD7 & CD 4. Results: There was statistically significant difference between MF and BCID with increased TOX, CD7 & CD4 expression among MF than among BCID and ability of TOX to detect all true positive cases (100.0%) compared to 83.3% for CD4 and 13.3% for CD7. TOX had the highest sensitivity (100.0%) and accuracy (88.3%) followed by CD4 with sensitivity of 88.3% and accuracy of 66.7%, (P < 0.001). Conclusion: TOX had the highest sensitivity (100.0%) & accuracy (88.3%) followed by CD4 with sensitivity of 88.3% and accuracy of 66.7%. Our results suggest that TOX is a useful marker in diagnosis of MF & differentiating it from BCID. | ||
| Keywords | ||
| TOX; CD7; CD4; Mycosis fungoides (MF); Benign cutaneous inflammatory diseases (BCID); Immunohistochemistry | ||
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