Selenium nanoparticles coated with resveratrol ameliorates the neurobiochemical abnormalities by attenuating oxidative stress and improving neurotransmissions in AlCl3-Induced Alzheimer’s model of rats. | ||
| Benha Veterinary Medical Journal | ||
| Article 38, Volume 41, Issue 1, October 2021, Pages 173-177 PDF (1.19 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bvmj.2021.75561.1406 | ||
| Authors | ||
| omayma ragab Abo zaid1; Samy Aziza1; Sawsan Mohammed EL-sonbaty2; Mohsen Afifi* 3 | ||
| 1Biochemistry veterinary medicine Banha university | ||
| 2Radiation Microbiology Department, National Centre for Radiation Research and Technology. Egypt. | ||
| 3Department of Biochemistry, Faculty of Veterinary Medicine, Benha University, Egypt | ||
| Abstract | ||
| Aluminium chloride is a neurotoxin that has been linked to the cause of Alzheimer's disease (AD) for decades. In situ, long-term aluminium toxicity causes oxidative stress and raises amyloid beta levels. Treatment options for Alzheimer's disease now only include symptomatic relief, necessitating the creation of alternative medications with fewer side effects. The researchers wanted to see whether long-term administration of resveratrol coated with Selenium nanoparticles (RSV-Nanoselenium) could shield rats from aluminum-induced AD pathogenesis and oxidative injury. In this study male albino wistar rats were orallyadministered withaluminum chloride (300 mg/kg b.wt)once daily for 30 days for induction of AD. The rats of induced model of AD were orally administrated with RSV-Nanoselenium (200 mg/kg, b.wt)once daily for 3 weeks.The rats were scarified on the 52ndand brain tissue of each rat was dissected and frozen at −80 °C. Biochemical research was conducted to determine the degree of oxidative injurythrough measuring Catalase, Glutathione (GSH), Malondialdehyde (MDA), γ-Secretase and Calcium levels in brain tissue.Aluminium chloride administration caused neurotoxicity and severe memory loss, as well as significant oxidative harm. It also resulted in substantial rise in γ-secretase and a significant decrease in calcium levels. RSV-Nanoselenium administration increased neuronal transmission by reducing oxidative stress and metal chelation in AD model of rats (P< 0.05). RSV-Nanoselenium protects against AD and oxidative harm caused by aluminium. | ||
| Keywords | ||
| Resveratrol; Nanoselenium; AD; Neurotransmission; Neurotoxicity | ||
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