TRIALS FOR PRODUCTION OF ALUMINUIUM HYDROXIDE GEL AND OILY ADJUVANT INACTIVATED NEWCASTLE DISEASE VACCINES, IN COMPARISON WITH COMMERCIAL IMPORTED OILY VACCINE | ||
| Assiut Veterinary Medical Journal | ||
| Article 10, Volume 27.1, Issue 53, April 1992, Pages 123-133 PDF (1.86 M) | ||
| Document Type: Research article | ||
| DOI: 10.21608/avmj.1992.210052 | ||
| Authors | ||
| NADIA HASSAN; ENSAF KHASHABA; FEKRIA EL-BORDINY; SALWA EL-ASILY; ELHAM EL—EBIARY; S. WAHBA; NARGIS BARHOMA | ||
| Abstract | ||
| inactivated Newcastle disease virus (NDV) vaccines were prepared in aluminium gel [A1(OH),] and oil emulsion (OE) adiuvants and compared with a commercially produced oil edjuvant vaccine. The lentogenic Hitchner B1 strailfigvas chosen as the best virus seed, giving an allantoic fluid titre of 10 /ml. egg inlective dosesu and 7 log, haemagg|utinat- ion titre. Virus inactivation was completed at 18 hours with final con- centration ol formalin at ‘l:1UDO. Both oil emulsion and aluminium gel vaccines were safe and immunogenic. The OE vaccine prepared from local oils had a high viscosity and was unsuitable for field use. Both OE and A1(OH), vaccines gave 80% protection for 6 months, with geometric mean haemagglutination inhibition (HI) titers of 3.5 and 2.8 respectively with the A1 (OH), the protection percent was 93, B3 and 79 for the first, second and third month respectively. The protection percent dropped to 70, 65 and 60 in the forth, filth and sixth month respectively. | ||
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