Serum biomarkers of hepatocellular carcinoma in patients with liver cirrhosis: a narrative review

Mohamed, Salem Youssef; Esmaiel, Ahmed Elsayed; Shabana, Marwa Abo; Ibrahim, Nevin Fouad

doi:10.21608/ajgh.2021.210293

	Serum biomarkers of hepatocellular carcinoma in patients with liver cirrhosis: a narrative review
African Journal of Gastroenterology and Hepatology
Article 5, Volume 4, Issue 1, July 2021, Pages 33-43
Document Type: Mini-reviews Articles
DOI: 10.21608/ajgh.2021.210293
Authors
Salem Youssef Mohamed¹; Ahmed Elsayed Esmaiel^* ²; Marwa Abo Shabana³; Nevin Fouad Ibrahim⁴
¹Internal Medicine Department, gastroenterology and hepatology unit, faculty of medicine, zagazig university, Egypt
²Liver center, ministry of health, Kafr Elsheikh, Egypt
³Clinical Pathology Department, Faculty of Medicine, Zagazig University, Egypt
⁴Internal Medicine Department, Faculty of Medicine, Zagazig University, Egypt
Abstract
Background: Hepatocellular carcinoma (HCC) is the sixth leading cause of cancer-related mortality worldwide and the most frequent type of primary liver cancer. HCC is diagnosed in the laboratory using either fine-needle cytology, which is invasive and has intra- or inter-observer variability or measuring circulating biomarkers. In combination with ultrasonography and computed tomography, several prognostic and diagnostic indicators are helpful in the clinical practice of screening and diagnosing HCC. Aim of work: To give an overview of serum biomarkers of HCC.
Keywords
Hepatocellular Carcinoma; Cirrhosis; Serological Markers; Alpha-fetoprotein
Supplementary Files Serum biomarkers of hepatocellular carcinoma in patients with liver cirrhosis.docx
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