ARTESUNATE COMBINED WITH PRAZIQUANTEL THERAPY MODULATE THE ANTIBODY RESPONSE IN MURINE SCHISTOSOMIASIS MANSONI | ||
| Journal of the Egyptian Society of Parasitology | ||
| Article 3, Volume 51, Issue 3, December 2021, Pages 443-450 PDF (1.47 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jesp.2021.210419 | ||
| Authors | ||
| NEVEEN A. MADBOULY; AZZA M. EL AMIR | ||
| Department of Zoology, Faculty of Science, Cairo University, Giza, Egypt | ||
| Abstract | ||
| This study evaluated the efficacy of praziquantel (PZQ), artesunate (AS) alone and combined PZQ-AS targeting Schistosoma mansoni immature-21days old schistosomula. PZQ & AS were administrated in a single oral dose (500 & 400mg/kg, respectively) alone or in combination 21 days post-infection (PI). Infected mice were sacrificed 56 days PI, parasitological, histological parameters and serum anti-SEA antibodies were evaluated. PZQ-monotherapy didn’t significantly affect total worm burden (TWB), female worm fecundity (FWF) or tissue egg load. AS-monotherapy significantly reduced TWB by 69.93%, FWF by 61.56% & tissue ova (hepatic by 91.54%& intestinal by 91.04%).Also, PZQ-AS combined treatment (21 days PI) significantly enhanced the developed worm eradication by 89.69%, FWF by 93.98% with maximal reduction of hepatic and intestinal egg load by 97.08 & 96.96%, respectively. Livers showed diminished granulomata when PZQ-AS was given 3 weeks PI with maximal drop in serum levels of anti-SEA specific IgM, total IgG, IgG1 & IgG2 antibodies. | ||
| Keywords | ||
| Schistosoma mansoni; Chemotherapy; Artesunate; Praziquantel; Immunoglobulins | ||
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