ASSESSMENT OF POSSIBLE SYNERGISTIC EFFECT OF BISPHOSPHONATES AND STATINS IN MURINE EXPERIMENTAL TOXOPLASMOSIS GONDII | ||
| Journal of the Egyptian Society of Parasitology | ||
| Article 18, Volume 51, Issue 3, December 2021, Pages 577-584 PDF (965.81 K) | ||
| DOI: 10.21608/jesp.2021.210447 | ||
| Authors | ||
| NADA R. MOHAMED1; AZZA I. H. YOUNIS1; RABAB S. ZALAT2; NAGLAA F.A. IMAM1 | ||
| 1Department of Medical Parasitology, Faculty of Medicine, Cairo University | ||
| 2Department of Medical Parasitology, Theodore Bilharz Research Institute | ||
| Abstract | ||
| This open new horizons for drug repositioning to standard used drugs in treatment of acute toxoplasmosis. This study was conducted on 70 male Albino mice in Theodore Bilharz Research Institute (TBRI) to evaluate the possible synergistic effect of risedronate sodium (Bisphosphonates) combination with atorvastatin (statins) on acute Toxoplasma gondii (RH strain) infected mice versus the drug spiramycin (macrolides). Drug combination was used in two doses: the first combined dosage was 0.01mg/kg/day risedronate sodium and 1.25mg/kg/ day atorvastatin (G B+S1) and the second one was 0.2mg/kg/day risedronate sodium and 20 mg/kg/day atorvastatin (G B+S2) and each drug of them was also used alone at a dose of 0.4 mg/kg/day for risedronate sodium (G B) and 40mg/kg/day for atorvastatin (G S) in comparison to spiramycin (G M) which was used at a dose of 200mg/kg/day. Microscopy examination by Giemsa stained of peritoneal exudate from T. gondii infected mice showed reduction in number of Toxoplasma tachyzoites to 86.28% on the 5th day post infection (G B+S1), 98.35% in (G B+S2), 98.27% in (G B) and 85.03% in (G S) and spiramycin treated mice with reduction of 93.66%. Histopathological examination of liver sections collected from infected mice showed remarked significant improvement in mice treated with combined of risedronate sodium and atorvastatin. | ||
| Keywords | ||
| Mice; Toxoplasma gondii; Risedronate sodium; Atorvastatin; Spiramycin | ||
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