Ameliorative Effect of Cerium Oxide Nanoparticles against Cadmium Nephrotoxicity in Male Albino Rats | ||
| Journal of Veterinary Medical Research | ||
| Article 3, Volume 28, Issue 2, December 2021, Pages 62-75 PDF (1005.57 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jvmr.2021.105032.1045 | ||
| Authors | ||
| Mostafa Bashandy1; Hanan Saeed* 2; Walaa Ahmed2; Marwa Ibrahim3; Olfat Shehata2 | ||
| 1Department of Clinical Pathology, Faculty of Veterinary Medicine, Cairo University. Egypt. | ||
| 2Department of Clinical Pathology, Faculty of Veterinary Medicine, Beni-Suef University, Beni-Suef 62511, Egypt. | ||
| 3Department of Biochemistry and Molecular Biology, Faculty of Veterinary Medicine, Cairo University, Egypt. | ||
| Abstract | ||
| The present study was done to investigate the nephroprotective effect of cerium oxide nanoparticles (CeO2NPs) on cadmium (Cd) toxicity in rats through the evaluation of some hematological parameters and serum biochemical constituents. One hundred and twenty male albino rats were separated into 6 equal groups. In group (I) rats were received distilled water orally and kept as a control group. Rats in the group (II and III) were injected i.p with cerium oxide nanoparticles at a dose of 0.1 mg/kg and 0.5 mg/kg, b.wt respectively twice weekly for 2 weeks from the 15th day till the end of the study. In group (IV) rats were received cadmium chloride by oral gavage daily (10 mg/kg, b.wt) for 28 days. Group (VandVI) rats were given cadmium chloride by oral gavage (10 mg/kg, b.wt) for 28 days and injected i.p with CeO2NPs at a dose of 0.1 mg/kg and 0.5 mg/kg, b.wt respectively twice weekly from the 15th day till the end of the study. Administration of cadmium resulted in normocytic normochromic anemia, leucocytosis (lymphocytic leucocytosis) then followed by leucopenia and lymphopenia accompanied by thrombocytopenia. The protein profile, high-density lipoproteins (HDL-C), superoxide dismutase (SOD), reduced glutathione (GSH) enzymes, and sodium levels were significantly decreased. Significantly elevated values of total cholesterol, triglycerides, MDA, and renal markers (urea and creatinine) with misbalanced electrolytes and minerals were noticed. The cerium oxide nanoparticles treatment may improve somewhat reversed effects of Cd on hematological and biochemical alterations, especially when compared with cadmium treated group (group IV). | ||
| Keywords | ||
| Nephrotoxicity; Cadmium; Nanoceria; Oxidative stress; Biochemical changes | ||
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