Structure and Function Changes of the Organ of Corti After Use of Sildenafil Citrate (VIAGRA®), in Adult Male Guinea Pigs | ||
| Egyptian Journal of Ear, Nose, Throat and Allied Sciences | ||
| Article 34, Volume 23, Issue 23, January 2022, Pages 1-6 PDF (858.31 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejentas.2021.96751.1419 | ||
| Author | ||
| REHAM FAROIK ZITTOON* | ||
| ENT FACULTY OF MEDICINE SUEZ CANSL UNIVERSITY ISMALLIA | ||
| Abstract | ||
| Background: Sildenafil citrate has been reported to induce temporary sensorineural hearing loss,tinnitus and dizziness. Objective: To evaluate the effects of sildenafil citrate on the guinea pigs cochlear structure and function using Otoacoustic Emissions (OAEs) and light microscopic H & E cochlear sections. Patients and Methods: This experimental study was conducted on 45 healthy adult male pigmented guinea pigs in Otolaryngology-Head and neck Surgery and Histology Departments in Suez Canal University, Ismailia-Egypt. Animals were randomly divided into three groups: Group 1 (n=15): control group. Group 2 (n=15): received the therapeutic dose of sildenafil citrate. Group 3 (n=15): received double the therapeutic dose of sildenafil citrate. Results: DPOAEs recorded from the three groups showed that the lowest amplitude was at 1006 kHz (10.4dB) and the highest at 6060 & 8084 kHz (43.9 & 42.1dB) respectively without statistically significant intergroup difference. In the H & E cochlear sections, there was disorganization and vacuolation of almost all cells of organ of Corti in group 2 and 3 compared to group 1. Lightly stained cytoplasm, karryorrhectic nuclei and pyknotic ones were also seen. These changes were more marked in group 3 which showed also some cellular loss in some sections. Conclusion: Therapeutic dose of sildenafil citrate affects the cellular structure of organ of corti without detectable effects in DPOAEs. | ||
| Keywords | ||
| Histology; Inner ear; otoacoustic emissions; sensorineural hearing loss; sildenafil citrate | ||
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