Association between Lipid Levels and Short-Term Heart Rate Variability (HRV) In Type 2 Diabetes | ||
| Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology | ||
| Article 3, Volume 14, Issue 1, June 2022, Pages 21-30 PDF (761.21 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/eajbsc.2022.213921 | ||
| Authors | ||
| S. Vijayabaskaran1; Dhanashree. B.2; V. Damodaran3; S. Nagarajan4 | ||
| 1Department of Physiology, PSG Institute of Medical Sciences and Research, Peelamedu, Coimbatore, Tamil Nadu, India – 641004 | ||
| 2PSG Institute of Medical Sciences and Research, Peelamedu, Coimbatore, Tamil Nadu, India – 641004. | ||
| 3MD (Community medicine) PGDHP, Institute of Community Medicine, Madras Medical College, Chennai – 600003 | ||
| 4MS (ENT) (AIIMS), FRCS (Eng), FRCS (Ed), OT ENT Centre, R S Puram, Coimbatore – 641002. | ||
| Abstract | ||
| Background: There are plenty of studies available to demonstrate the effect of diabetes on short-term Heart Rate Variability (HRV) but not enough about lipids, especially in our region. Hence, we aimed to study the influence of total cholesterol and individual lipid fractions on short-term HRV in type 2 diabetics. Methods: As per the set criteria, 70 newly diagnosed type 2 diabetics were recruited and grouped based on their cholesterol levels. Both the time domain and the frequency domain measures of short-term HRV were acquired and subjected to statistical analysis. This was a cross-sectional observational study. Results: Elevated total cholesterol group showed a reduction in Standard deviation of all NN intervals (SDNN) and High Frequency (HF) power and an increase in Low-Frequency power / High-Frequency power (LF/HF) ratio in comparative analysis. Similarly, the high low-density lipoproteins (LDL) group showed a decrease in square root of the mean of the sum of the squares of the differences between adjacent NN intervals (SDNN) and RMSSD but a rise in LF/HF ratio. Moreover, total cholesterol is negatively correlated with SDNN, RMSSD, and HF power while total cholesterol and LDL are positively correlated with LF/HF ratio. Total cholesterol, LDL, and triglycerides had an independent association with HF. Conclusions: Our study shows higher levels of total cholesterol, LDL and triglycerides decrease cardiovagal activity. Hence, based on this we conclude abnormal lipid levels depress HRV | ||
| Keywords | ||
| HRV; lipids; total cholesterol; LDL; triglycerides | ||
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