Combination of Insulin Sensitizer and Omega-3 Fatty acids might minimize the risk for Cardiac events in PCOS women | ||
| The Egyptian Journal of Fertility and Sterility | ||
| Article 3, Volume 26, Issue 1 - Serial Number 11106352, January 2022, Pages 23-37 PDF (3.38 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/egyfs.2022.216263 | ||
| Author | ||
| Basma Sakr | ||
| Department of Obstetrics & Gynecology, Faculty of Medicine, Benha University | ||
| Abstract | ||
| Objectives: Evaluation of the effect of 3 months therapy of metformin/omega-3 (M/O) combination on body mass index (BMI), insulin resistance (IR), and oxidative and inflammatory milieu in PCOS women at probable cardiac risk (CR) as predicted by the atherogenic index of plasma (AIP). Patients and methods: 90 PCOS women were randomly allocated into the M group received metformin (500 mg bi-daily) and M/O group received metformin (500 mg bi-daily) and Omega3 (950 mg active omega-3 once daily). Pre- and Post-treatment BMI, Homeostasis model assessment for IR (HOMA-IR), AIP and serum tumor necrosis factor-α (TNF-α), interleukin (IL)-β, superoxide dismutase (SOD), and malondialdehyde (MDA) levels were evaluated. The primary outcome is the effect of provided 3-m therapy AIP. Results: Pre-treatment AIP defined 15.6% and 58.9% of studied women had high or intermediate cardiac risk (CR), 59 women were obese, 16 women were morbidly obese, and 52 women were insulin resistant with elevated serum levels of TNF-α, IL-1β, MDA, and lower serum SOD levels. Combined therapy allowed a significant decrease in HOMA-IR score, serum TNF-α, IL-1β, and MDA levels with significant elevation of serum SOD. Combination therapy significantly reduced the AIP in comparison to pre-treatment AIP and to that of women of the M group. Moreover, no woman still had high CR after M/O therapy and the frequency of women who had low CR was increased by about 107%. Conclusion: Insulin sensitizers could improve PCOS-associated disturbances. However, omega-3 adjuvant therapy significantly augmented the effects of insulin sensitizers, minimized the cardiac risk factors, and decreased the risk of probable cardiac events. | ||
| Keywords | ||
| PCOS; Omega 3; Metformin; Atherogenic index of plasma; Cardiac risk | ||
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