Abd El-Ghany, H., Abdel Gawad, E., Esmaeel, M., Moneer, M., Fathy, A., Elshafei, A., Othman, M., Mohamed, A., Rabie, M. (2020). Magnetic resonance imaging of multiple sclerosis. test, 31(4), 172-177. doi: 10.21608/mjmr.2022.217922
Hosny S. Abd El-Ghany; Enas A. Abdel Gawad; Mohamed M. Esmaeel; Mahmoud M. Moneer; Alaa W. Fathy; Ahmed M. Elshafei; Mohamed F. Othman; Asmaa A. Mohamed; Mahmoud E. Rabie. "Magnetic resonance imaging of multiple sclerosis". test, 31, 4, 2020, 172-177. doi: 10.21608/mjmr.2022.217922
Abd El-Ghany, H., Abdel Gawad, E., Esmaeel, M., Moneer, M., Fathy, A., Elshafei, A., Othman, M., Mohamed, A., Rabie, M. (2020). 'Magnetic resonance imaging of multiple sclerosis', test, 31(4), pp. 172-177. doi: 10.21608/mjmr.2022.217922
Abd El-Ghany, H., Abdel Gawad, E., Esmaeel, M., Moneer, M., Fathy, A., Elshafei, A., Othman, M., Mohamed, A., Rabie, M. Magnetic resonance imaging of multiple sclerosis. test, 2020; 31(4): 172-177. doi: 10.21608/mjmr.2022.217922

Magnetic resonance imaging of multiple sclerosis

Minia Journal of Medical Research
Volume 31, Issue 4, October 2020, Pages 172-177    PDF (175.12 K)
Document Type: Original Article
DOI: 10.21608/mjmr.2022.217922
Authors
Hosny S. Abd El-Ghany1; Enas A. Abdel Gawad2; Mohamed M. Esmaeel3; Mahmoud M. Moneer2; Alaa W. Fathy2; Ahmed M. Elshafei4; Mohamed F. Othman4; Asmaa A. Mohamed4; Mahmoud E. Rabie4
1Department of Radiology, El-Minia Faculty of medicine, El-Minia- Egypt
2Department of Radiology, El-Minia Faculty of medicine, El-Minia- Egypt.
3Department of Neurology and Psychiatry, El-Minia Faculty of medicine, El-Minia- Egypt.
4Department of Ophthalmology, El-Minia Faculty of Medicine
Abstract
Background: Magnetic resonance imaging (MRI) has an important role in early diagnosis of 
MS. Multiple sclerosis (MS) is a demyelinating disease of the central nervous system. 
Patients and Methods: forty patients clinically diagnosed to have MS according to 
McDonald criteria were included and referred to department of radio-diagnosis, Faculty of 
Medicine, Minia University. Imaging was performed on a 1.5T Philips MR system using 
double inversion recovery (DIR), fluid attenuated inversion recovery (FLAIR), T2-weighted, 
T1-weighted and susceptibility-weighted imaging (SWI) sequences with the parameters 
including field of view (FOV), matrix, slice thickness and voxel size. They were done after 
the approval of ethical committee of our institution. Data analysis was performed using the 
SPSS version 20 and p-value as well as comparative study were gained. Results: The 
detection rate of white matter lesions in T2 was (80%); while for grey matter lesions was 
(12%). In FLAIR sequence, we found that; the detection rate of white matter lesions was 
(97%); while for grey matter lesions was (26%). As regarding DIR sequence, the detection 
rate of white matter lesions was (93%); while for grey matter lesions was (95%).Comparative 
study between serial MRI sequences (T2,FLAIR and DIR) revealed; significant increase in 
detected number of grey matter lesions; in DIR-MRI sequence (p < 0.0001). In SWI, a central 
vein sign was detected in 97 lesions (66 in periventricular lesions and 31 in subcortical 
lesions). Conclusion: From this study we concluded that new imaging modalities of MRI as 
regarding DIR and SWI are a valuable MRI sequences in imaging of multiple sclerosis; thus, 
we recommend adding DIR and SWI sequences in routine MR protocols for MS patients.

Keywords
MRI; multiple sclerosis; Double inversion recovery (DIR); SWI; T2; FLAIR
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