Immunohistochemical study of FoxA1 in Invasive Duct Carcinoma of the Breast and Corresponding Lymph Node Metastasis | ||
| Minia Journal of Medical Research | ||
| Volume 31, Issue 4, October 2020, Pages 268-281 PDF (785.75 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/mjmr.2022.218138 | ||
| Authors | ||
| Azza M. Abelzaher; Manal E. Abdelghany; Nehad M.Reda Abdel maqsoud; Heba M. Tawfiq; Wafaa F. Aref | ||
| Department of Pathology, El-Minia Faculty of Medicine | ||
| Abstract | ||
| FoxA1 (forkhead box protein A1) is one of three members in the FoxA related family (forkhead family of transcriptions factors). FoxA related family proteins are often termed “pioneer factors” because of their ability to bind to highly compacted heterochromatin and making genomic regions more accessible to other transcription factors. This study aimed to evaluate the clinical significance of FoxA1 expression in invasive duct carcinoma of the breast and in corresponding lymph node metastasis. FoxA1 expression was examined in 70 tumor tissues plus 53 paraffin blocks of corresponding lymph node metastasis by immunohistochemistry. The association between expression of this marker and clinicopathologic parameters was analyzed. Also comparison between FoxA1 expression in the primary tumor and corresponding lymph node metastasis was done in 53 pairs. FoxA1 was positive in (45.7%) of cases. FoxA1 expression was associated with tumor grade (p= 0.046), lymph node status (>3 lymph nodes) (p = 0.049), tumor stage (p=0.009), prognostic stage (p=0.001), good Nottingham prognostic index (p=0.042), ER and PR positivity (p=0.028 and 0.033 respectively), Her2 negativity (p= 0.019), Molecular subtypes (p=0.038) and distant metastasis (p=0.004). As regard FoxA1 expression in primary tumor and corresponding lymph node metastasis, 96.2% of pairs revealed a concordance between the primary tumor and corresponding lymph node metastasis and only 2 cases (3.8%) were nonconcordant but the results weren’t statistically significant. These findings suggest that FoxA1 expression can be considered as a good prognostic and therapeutic marker for targeted therapy of breast cancer patients. | ||
| Keywords | ||
| FoxA1 | ||
|
Supplementary Files
|
||
|
Statistics Article View: 75 PDF Download: 317 |
||
