Fouda, M., El-Shimi, O., Mahgoub, M., Abdelrahman, S., MN Abdelrahman, A. (2022). Evaluation of Urinary and Serum Macrophage Migration Inhibition Factor in a group of Systemic Lupus Erythematosus Egyptian Patients. test, 39(1), 164-178. doi: 10.21608/bmfj.2022.103168.1509
Mona Fouda; Ola El-Shimi; Marwa Mahgoub; Samar Abdelrahman; Amira MN Abdelrahman. "Evaluation of Urinary and Serum Macrophage Migration Inhibition Factor in a group of Systemic Lupus Erythematosus Egyptian Patients". test, 39, 1, 2022, 164-178. doi: 10.21608/bmfj.2022.103168.1509
Fouda, M., El-Shimi, O., Mahgoub, M., Abdelrahman, S., MN Abdelrahman, A. (2022). 'Evaluation of Urinary and Serum Macrophage Migration Inhibition Factor in a group of Systemic Lupus Erythematosus Egyptian Patients', test, 39(1), pp. 164-178. doi: 10.21608/bmfj.2022.103168.1509
Fouda, M., El-Shimi, O., Mahgoub, M., Abdelrahman, S., MN Abdelrahman, A. Evaluation of Urinary and Serum Macrophage Migration Inhibition Factor in a group of Systemic Lupus Erythematosus Egyptian Patients. test, 2022; 39(1): 164-178. doi: 10.21608/bmfj.2022.103168.1509

Evaluation of Urinary and Serum Macrophage Migration Inhibition Factor in a group of Systemic Lupus Erythematosus Egyptian Patients

Benha Medical Journal
Article 12, Volume 39, Issue 1, March and April 2022, Pages 164-178    PDF (690.21 K)
Document Type: Original Article
DOI: 10.21608/bmfj.2022.103168.1509
Authors
Mona Fouda1; Ola El-Shimi2; Marwa Mahgoub3; Samar Abdelrahman* 4; Amira MN Abdelrahman5
1professor of Clinical and Chemical Pathology, Faculty of Medicine, Benha University, Egypt
2Assistant professor of Clinical and Chemical Pathology, Faculty of Medicine, Benha University, Egypt.
3Assistant professor of Rheumatology and Rehabilitation, Faculty of Medicine, Benha University, Egypt
4Assistant lecturer of Clinical and Chemical Pathology, Faculty of Medicine, Benha University, Egypt
5Assistant professor of Clinical and chemical pathology, Faculty of Medicine, Benha University
Abstract
Objective: to evaluate the potential clinicopathological involvement of macrophage migration inhibitory factor (MIF) in systemic lupus erythematosus (SLE), and its relationship with lupus nephritis (LN) through measuring serum and urinary MIF levels.
Methods: A cross-sectional case-control study was carried out on 30 SLE female patients and 30 healthy age-matched females as a control group. SLE activity was assessed by the Systemic Lupus Erythematosus Disease Activity Index-2000 (SLEDAI-2k) and renal activity was evaluated with the renal-SLEDAI (rSLEDAI-2k). SLE damage was evaluated by the Systemic Lupus International Collaborating Clinics/American College of Rheumatology (SLICC/ACR) damage index. Serum MIF (sMIF), urinary MIF (uMIF) levels were assayed and uMIF/creatinine ratio was estimated in all studied subjects.
Results: SLE patients had significantly higher levels of sMIF, uMIF and uMIF/ creatinine ratio than the control group (p < /p>
Keywords
Systemic lupus erythematosus; MIF; lupus nephritis; lupus biomarkers
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