Maghraby, M., Fathy, R., Atta, S., Mostafa, M., Sayed, A., Ismael, T., Abdelraouf, H., Abdelrahman, G. (2022). Association Between Type 2 Diabetes Mellitus and TCF7L2 And FTO Gene Variants Among Upper Egyptian Population. test, 86(1), 933-942. doi: 10.21608/ejhm.2022.219966
M. Hossam Maghraby; Refat Fathy; Sara Abdel-Reheem Atta; Mohammed Hassan Mostafa; Ayat A. Sayed; Taghreed A. Ismael; Heba M. Abdelraouf; Ghada Abdelrahman. "Association Between Type 2 Diabetes Mellitus and TCF7L2 And FTO Gene Variants Among Upper Egyptian Population". test, 86, 1, 2022, 933-942. doi: 10.21608/ejhm.2022.219966
Maghraby, M., Fathy, R., Atta, S., Mostafa, M., Sayed, A., Ismael, T., Abdelraouf, H., Abdelrahman, G. (2022). 'Association Between Type 2 Diabetes Mellitus and TCF7L2 And FTO Gene Variants Among Upper Egyptian Population', test, 86(1), pp. 933-942. doi: 10.21608/ejhm.2022.219966
Maghraby, M., Fathy, R., Atta, S., Mostafa, M., Sayed, A., Ismael, T., Abdelraouf, H., Abdelrahman, G. Association Between Type 2 Diabetes Mellitus and TCF7L2 And FTO Gene Variants Among Upper Egyptian Population. test, 2022; 86(1): 933-942. doi: 10.21608/ejhm.2022.219966

Association Between Type 2 Diabetes Mellitus and TCF7L2 And FTO Gene Variants Among Upper Egyptian Population

The Egyptian Journal of Hospital Medicine
Article 152, Volume 86, Issue 1, January 2022, Pages 933-942    PDF (736.67 K)
Document Type: Original Article
DOI: 10.21608/ejhm.2022.219966
Authors
M. Hossam Maghraby; Refat Fathy; Sara Abdel-Reheem Atta* ; Mohammed Hassan Mostafa; Ayat A. Sayed; Taghreed A. Ismael; Heba M. Abdelraouf; Ghada Abdelrahman
biochemistry, faculty of medicine, Assiut university, Assiut, Egypt
Abstract
Background: Type 2 diabetes mellitus (T2DM) is a metabolic disorder caused by a complex interaction of genetic and environmental variables. T2DM is associated with transcription factor 7-like 2 (TCF7L2) and fat mass and obesity- associated (FTO) genetic polymorphism.
Objectives: The goal of this study was to examine the common genetic risk factors of T2DM and related metabolic traits in Upper Egyptian population, in attempt to understand the genetic structure of T2DM in the Egyptian community. Methods and Materials: This case control study included 250 participants, 124 T2DM patients and 126 non-diabetics. Using mutagenically separated polymerase chain reaction (MS-PCR), genotyping of single nucleotide polymorphisms (SNP) rs7903146 of TCF7L2 and rs17817449 of FTO genes was carried out.
Results: T allele of TCF7L2 variant rs7903146 confers a risk for T2DM (allelic OR=1.97, 95% CI: (1.34 to 2.88) p =<0.001). The minor G allele of FTO rs17817449 polymorphism was significantly higher in diabetics than controls (allelic OR=1.87, 95% CI=1.30 to 2.68, p < 0.001). Genotype risk was evident under both recessive and dominant modes of inheritance (OR=3.18, CI (1.35-7.45), P =0.008, OR= 2.04, CI (1.23-3.38), p=0.006) for TCF7L2 and (OR= 2.55, CI (1.28 -5.09), p=0.008 and OR= 2.14, CI (1.25-3.63), p= 0.005) for FTO respectively
Conclusion: TCF7L2 rs7903146 and FTO rs17817449 variant conferred risk for T2DM in Upper Egyptian population. The study noted the interaction between certain biological and environmental risk factors including BMI, age, and sex and the conferred genetic risk.

Keywords
FTO gene; Obesity; T2DM; TF7L2 gene
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