The role of laboratory markers as predictors of severity in Covid 19 patients | ||
| Minia Journal of Medical Research | ||
| Volume 31, Issue 3, July 2020, Pages 367-380 PDF (494.72 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/mjmr.2022.220320 | ||
| Author | ||
| Mariam F. Abdelmaksoud, | ||
| Department of Clinical Pathology, Ain-Shams University | ||
| Abstract | ||
| Background: The pandemic due to novel coronavirus 19 has spread at a tremendous rate to more than 93 countries around the world. Many studies evaluated the role of laboratory markers in the diagnosis of the disease. However, their role in predicting non severe, severe, and post covid 19 cases is being explored. Aim of the study: To evaluate the role of laboratory markers in predicting the prognosis of covid 19 cases and in predicting the evolution of post covid 19 sequalae. Subjects and methods: This retrospective study included 650 Covid 19 patients; furtherly classified as 386 non severe patients; 200 severe patients, and 64 post covid patients. Complete blood count (CBC), Creactive protein (CRP), serum ferritin, D dimer, and Alanine Aminotransferase (ALT) were measured in all patients. Results: Higher CRP, ferritin, D dimer, ALT, total leucocytic count (TLC), absolute neutrophil and monocytic counts, neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) were significantly found in severe covid 19 cases when compared to non severe and post covid recovered cases, together with lower absolute lymphocytic and eosinophil counts, hemoglobin (Hb), and lymphocyte to monocyte ratio (LMR). Moreover, post covid spontaneous recovery showed a decline in all laboratory markers together with a rise in lymphocytic and eosinophil counts, Hb level, platelet (PLT) count, and LMR upon convalescence. The multivariate regression analysis showed that ICU admission, dyspnea, low absolute lymphocyte count, high TLC, and high absolute monocyte counts are independent risk factors for the severity of covid 19. Conclusion: Laboratory markers are fast, simple, cost effective tools to stratify covid cases into non severe and severe and to predict the course of post covid cases. Hence, allowing the proper early intervention to each case. | ||
| Keywords | ||
| Covid 19; non severe; severe; post covid; laboratory markers; prognosis | ||
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