Malnutrition and vitamin D, what is the relation with sepsis? | ||
| Minia Journal of Medical Research | ||
| Volume 31, Issue 2, April 2020, Pages 196-200 PDF (248.11 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/mjmr.2022.221013 | ||
| Authors | ||
| Sawsen El-Banna1; Duaa Mahrous1; Hend Moonesl2; Noura A. Mahmoud1 | ||
| 1Departments of Pediatrics, Faculty of Medicine, Minia University, ElMinya, Egypt. | ||
| 2Departments of Clinical pathology, Faculty of Medicine, Minia University, El Minia, Egypt | ||
| Abstract | ||
| Background: Malnutrition affects 50% of hospitalized children and 25-70% of the critically ill children. It increases the incidence of complications and mortality. Malnutrition is associated with an altered metabolism of certain substrates, increased metabolism and catabolism depending on the severity of the lesion, and reduced nutrient delivery. also,. Vitamin D is essential for bone health, as well as for cardiovascular and immune function. In critically ill adults vitamin D deficiency (VDD) is common, and is associated with sepsis and higher critical illness severity. Objectives: Aim of the study: to determine the effect of malnutrition on mortality in Pediatric Intensive Care Unit (PICU) and neonatal intensive care unit in minia university hospital. Methods: This was a prospective study done over 6 month. There were total 220 patients (1 month to18 years), who were divided into cases with weight for age <3 (rd) centile and controls with ≥3(rd) centile of WHO charts. Cases were subdivided into mild/moderate (61-80% of expected weight for age) and severe malnutrition (<60%).. Blood was collected on admission to PICU and analyzed for 25-OH-D levels. The three groups: were subjected to complete history taking, through clinical examination and laboratory investigations including determining serum vitamin D level. Results: Out of total, 48% patients were underweight, and malnutrition was more in early childhood (P - 0.01) and were more deficient in serum vitamin D level (p 0.0001) Cases needed prolonged mechanical ventilation (P - 0.0001) and hospital stay (P - 0.0001) compared to controls. mortality was significantly higher in severely malnourished (P value 0.0001). The prevalence of VDD was associated with prolonged stay in intensive care unit (P0.0001), mechanical ventilation (p 0.005) . Conclusion: Severe malnutrition and vitamin D deficiency at PICU admission was prevalent in critically ill children and was associated with adverse clinical outcomes. | ||
| Keywords | ||
| Vitamin D; Anthropometric data; malnutrition; outcome in malnourished children; pediatric risk of mortality | ||
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