Immunohistochemical Expression of TWIST1 in Colorectal Adenocarcinoma | ||
| Minia Journal of Medical Research | ||
| Volume 31, Issue 2, April 2020, Pages 257-260 PDF (368.5 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/mjmr.2022.221057 | ||
| Authors | ||
| Heba M. Tawfik; Mariana F. Kamel; Maram El-Hussieny; Dalia M. Thabet | ||
| Department of Pathology, Faculty of Medicine, Minia University, Egypt. | ||
| Abstract | ||
| Background: Colorectal cancer is one of the most common cancers worldwide. It is the result of a complex genetic mutations and environmental factors. TWIST1 is expressed in a wide range of normal and neoplastic tissues and has emerged as an important regulator of diverse functions critical in cancer biology including cellular transition, proliferation, metastasis and gene expression. Methods: Immunohistochemical staining of TWIST1 was conducted on 50 tissue specimens of colorectal adenocarcinoma by using the avidin biotin-peroxidase complex method with diaminobenizidine chromagen detection system. Results: High TWIST1 expression was detected in 62% of cases. TWIST1 expression showed statistically significant correlation with lymph node metastasis (p= 0.007) and advanced tumor stage assessed by modified Dukes staging (p = 0.043). Conclusions: TWIST1 expression is significantly associated with poor prognostic factors and thus can be used as a prognostic indicator for colorectal carcinoma patients. | ||
| Keywords | ||
| TWIST1; Colorectal Carcinoma; Immunohistochemistry. All authors have no conflict of interest | ||
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