Targeting Apoptosis as a Therapeutic Approach in Cancer | ||
| Minia Journal of Medical Research | ||
| Volume 31, Issue 2, April 2020, Pages 321-334 PDF (506.18 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/mjmr.2022.221093 | ||
| Authors | ||
| Rania A. Abd-Elhamid1; Maiiada H. Nazmy2; Moustafa Fathy3 | ||
| 1Department of Biochemistry, Faculty of Pharmacy, Deraya University, Minia, Egypt | ||
| 2Department of Biochemistry, Faculty of Pharmacy, Minia University, Minia, Egypt | ||
| 3Department of Regenerative Medicine, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan | ||
| Abstract | ||
| Cancer is a major health problem worldwide, it has been known in its ability in evading and escaping apoptosis. All types of cancer cells gain resistance to apoptosis; they are prone to escape the normal cellular growth and death pathways result in uncontrollable division and proliferation. Apoptosis is programmed cell death or cell suicide; a process normally found in every eukaryotic cell. Damaged DNA triggers the cell to activate apoptotic machinery to remove itself from the body. Apoptosis is an extremely organized process: the cellular membranes are disrupted, the chromosomes are degraded, the DNA breaks up into fragments, and the dying shrinking cell is engulfed by immune cells in a clean and orderly manner. In this review, we will discuss the apoptotic pathways that can be used as a therapeutic target in cancer. | ||
| Keywords | ||
| apoptosis; apoptotic pathways; cancer; p53; cell cycle; cancer stem cell; miRNA | ||
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