Voltammetric method for determination of Palonosetron Hydrochloride in the presence of its degradant using synergistic effect of ZnO nanoparticles and carbon nanotubes in micellar media | ||
| Egyptian Journal of Chemistry | ||
| Article 57, Volume 65, Issue 10, October 2022, Pages 597-607 PDF (646.44 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejchem.2022.89142.5156 | ||
| Authors | ||
| Ola M. Abdallah1; Taghreed A. Mohamed2; hassan Hendawy2; Hager Elomda* 3 | ||
| 11. Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Al-Azhar University (Girls), Cairo, Egypt. 2. Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Egyptian Russian University in Egypt (ERU), Badr City, Cairo, Egypt. | ||
| 2Pharmaceutical Chemistry Department, Egyptian drug Authority, Giza, Egypt. | ||
| 3Egyptian Drug Authority, Giza, Egypt | ||
| Abstract | ||
| A highly sensitive nano-materials modified electrode was fabricated for the quantification of Palonosetron Hydrochloride (PAL) using anodic differential pulse voltammetry (A-DPV) for the first time. The synergetic effect of Multi-wall Carbon nano-tubes and nano-zinc oxide particles was utilized for the fabrication of the modified electrode (ZnO-NPs/CNTs/CPE). PAL oxidative degradant was prepared and the degradant’s identification and degradation pathway illustration were done by NMR and mass spectrometry. PAL quantification in 0.04M B-R buffer electrolyte solution (PH 7.0) using ZnO-NPs/CNTs/CPE showed peak response with linearity in the concentration range 6.50– 38.50 µM. The peak response showed a remarkable increase in micellar media upon the addition of Sodium Lauryl Sulfate (SLS). The minimum detectability (LOD) of PAL was 1.19 µM and the limit of quantification (LOQ) was 3.61 µM. The validation of the proposed method showed good accuracy, precision, and reproducibility compared to the official method. The approached technique which can be described as an environmentally friendly technique is rapid, sensitive, and inexpensive for PAL determination in the presence of its oxidative degradant, in its pharmaceutical vials, and biological fluids. | ||
| Keywords | ||
| Palonosetron Hydrochloride; differential Pulse voltammetry; multiwall carbon nanotube; Aloxi® injection vials; electrode; biological fluids | ||
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