Role of Guanosine in Glycerol Induced Acute Renal Failure in Rats | ||
| Minia Journal of Medical Research | ||
| Volume 31, Issue 1, January 2020, Pages 105-107 PDF (396.89 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/mjmr.2022.221409 | ||
| Authors | ||
| Salwa Hamdy; Ahmed Mohamed; Rasha Fouad; Wael farouk | ||
| Department of Biochemistry, Faculty of Medicine, Minia University | ||
| Abstract | ||
| Background: Acute renal failure (ARF) is a serious clinical problem with high rate of mortality and morbidity. Currently used prophylactic and therapeutic strategies to address ARF are limited and warrant further studies. In the present study an attempt was made to investigate the effect of guanosine against glycerol induced AKI in rats. Methods: Male Wistar rats were divided in to three groups. After 24 h of water deprivation rats in group 2 received glycerol once whereas rats in group 1 served as control. In group 3 rats received intraperitonial injection of guanosine then animals were sacrificed, blood and kidney were collected for various biochemical and histopathological studies. Results: Glycerol treatment produced significant renal structural abnormalities and functional impairment (increased urea and creatinine). Guanosine dose dependently attenuated glycerol induced structural and functional changes in kidney. Conclusion: The reversal of glycerol induced AKI by guanosine points towards a role in improve the pathogenesis of renal injury. The result of this study suggests that guanosine may offer an alternative mode of treatment for AKI. | ||
| Keywords | ||
| renal failure; guanosine; glycerol | ||
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