El-Badawi, A., Gaafar, A., Abbas, H., Authman, M. (2014). The protective role of copper nicotinate and vitamin E against neem seed oil induced oxidative stress and histopathological changes in Nile Tilapia (Oreochromis niloticus, Linnaeus, 1758). test, 18(3), 1-19. doi: 10.21608/ejabf.2014.2214
Ashraf El-Badawi; Alkhateib Gaafar; Hossam Abbas; Mohammad Authman. "The protective role of copper nicotinate and vitamin E against neem seed oil induced oxidative stress and histopathological changes in Nile Tilapia (Oreochromis niloticus, Linnaeus, 1758)". test, 18, 3, 2014, 1-19. doi: 10.21608/ejabf.2014.2214
El-Badawi, A., Gaafar, A., Abbas, H., Authman, M. (2014). 'The protective role of copper nicotinate and vitamin E against neem seed oil induced oxidative stress and histopathological changes in Nile Tilapia (Oreochromis niloticus, Linnaeus, 1758)', test, 18(3), pp. 1-19. doi: 10.21608/ejabf.2014.2214
El-Badawi, A., Gaafar, A., Abbas, H., Authman, M. The protective role of copper nicotinate and vitamin E against neem seed oil induced oxidative stress and histopathological changes in Nile Tilapia (Oreochromis niloticus, Linnaeus, 1758). test, 2014; 18(3): 1-19. doi: 10.21608/ejabf.2014.2214

The protective role of copper nicotinate and vitamin E against neem seed oil induced oxidative stress and histopathological changes in Nile Tilapia (Oreochromis niloticus, Linnaeus, 1758)

Egyptian Journal of Aquatic Biology and Fisheries
Article 1, Volume 18, Issue 3, September 2014, Pages 1-19    PDF (14.84 M)
Document Type: Original Article
DOI: 10.21608/ejabf.2014.2214
Authors
Ashraf El-Badawi1; Alkhateib Gaafar2; Hossam Abbas2; Mohammad Authman2
1Central Laboratory for Aquaculture Research, Abbassa, Abo-Hammad, Sharkia, Egypt. 2- Biological Department,University College,Umm Al-Qura University,Kingdom of Saudi Arabia.
2Hydrobiology Department, National Research Centre, Dokki 12622, Giza, Egypt.
Abstract
The aim of the current investigation was to evaluate whether neem (Azadirachta indica) seeds oil (NO) induced changes on some oxidative indicators and histopathological alterations in tissues of Oreochromis niloticus fish and the possible
protective effects of copper nicotinate (CN) and vitamin E on neem oil-induced changes. Fish were divided into 8 groups and treated with NO alone or in combination with CN, vitamin E and clean water. NO interfered with the antioxidant defense system of O. niloticus, as there was a decrease in GST, CAT and SOD activities in all studied organs as compared to control group. These alterations in antioxidantsactivities were accompanied with the occurrence of histological lesions and damage in  gills, liver and posterior kidney tissues. The addition of CN and Vitamin E in fish
diets could protect the fish O. nilotcus against NO-induced oxidative damage and histopathological changes showing recovery of fish organs. It was concluded that although botanical pesticides are being considered as less toxic/safe, but it may provoke deleterious changes in vital organs of the fish. Hence, precautions must be taken into account when botanicals are being used in fish production facilities. 
Keywords
Oreochromis niloticus; neem seed oil; Oxidative Stress; histopathology changes; copper nicotinate; Vitamin E
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