Synthesis and biological activity of some new fused thieno[2,3-b] pyridine derivatives; pyridothienopyrimidinones and pyridothienotriazinones | ||
| Assiut University Journal of Multidisciplinary Scientific Research | ||
| Volume 45, Issue 1, June 2016, Pages 47-57 PDF (462.96 K) | ||
| Document Type: Novel Research Articles | ||
| DOI: 10.21608/aunj.2016.221640 | ||
| Abstract | ||
| 3-Amino-4-aryl-5-ethoxycarbonyl-6-methylthieno[2,3-b]pyrindine-2-carboxamides 3a,b were prepared and reacted with triethyl orthoformate to give pyridothienopyrimidinone derivatives 4a,b. The reaction of compound 3b with potassium ethyl xanthate and/or phenyl isothiocyanate produced thioxopyridothieno-pyrimidinones 5 and 6 respectively. Diazotisation of compounds 3a,b led to the formation of 9-aryl-8-ethoxycarbonyl-7-methylpyrido[3’,2’:4,5]thieno[3,2-d] [1,2,3]triazine-4(3H)-ones (7a,b). Compounds 5, 6 and 7a,b underwent some reactions to furnish other new pyridothienopyrimidinones 8, 9a,b and pyridothienotriazinones 10-13a,b. The structural formulas of all newly synthesized compounds were confirmed by elemental and spectral analyses. Also, the biological activity of fifteen compounds as antibacterial and antifungal agents were studied. | ||
| Keywords | ||
| Thienopyridines; pyridothienopyridines; pyridothienotriazines; Mannich reaction | ||
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